Dr Lindley works at the interface of exercise metabolism, chemical biology, and clinical medicine. His research has explored the mechanism of action of Omega-3 long chain polyunsaturated fatty acids (fish oil), with a focus on inflammation and oxidative stress, cellular incorporation, genetic regulation, epigenetic change, protein expression and biomarker identification.
Dr Lindley is the academic lead for the Translational Chemical Biology research group, a Fellow of the Royal Society of Biology, and the Director of Biosciences in the School of Sport, Exercise and Health Sciences.
Dr Lindley’s current transdisciplinary work is engaging: analytical chemistry to analyse the metabolic processes involved in skeletal muscle contraction via volatile organic compounds (VOCs) in exhaled breath, and to work towards the synthesis of pro-resolution mediators; clinical medicine to investigate Omega-3 and respiratory health/COPD; and education to investigate the impact of nutritional status, systemic inflammation and oxidative stress on learning.
Learned Societies and Professional Affiliations
- UK Research Integrity Officer: Advisor
- Biochemical Society: Deputy Chair Clinical Translational Research Theme Panel (CTRTP)
- British Association of Sports and Exercise Science
- British Association of Sports Medicine
- British Thoracic Society
- European Respiratory Society
- American College of Sports Medicine
- American Thoracic Society
- International Society for the Study of Fatty Acids and Lipids
- Adjunct Professor - Federal University of Acre - Brazil
- Adjunct Assistant Professor - Indiana University - USA
Invited Lecture / Keynotes
- COVID-19 lifestyle education sessions - June 23rd 2020. Video: Introduction to the Immune System
- Association for Respiratory Technology and Physiology - Annual conference guest speaker February 2008
- UK Sport - Expert panel - The Brittle Athlete March 2008
- Nottingham University - 2004
- University of Wales College of Medicine - 2002
- Ward, T.J.C., Lindley, M.R., Ferguson, R.A., Constantin, D., Singh, S.J., Bolton, C.E., Evans, R.A., Greenhaff, P.L and Steiner, M.C. (accepted - 2020) Submaximal eccentric cycling in people with COPD: acute whole-body cardiopulmonary and muscle metabolic responses. Chest. Sep 1:S0012-3692(20)34312-9. doi: 10.1016/j.chest.2020.08.2082. Online ahead of print. PMID: 32888931
- Causer, A., Shute, J., Cummings, M., Shepherd, A., Gruet, M., Costello, J., Bailey, S., Lindley,M.R., Pearson, C., Connett, G., Allenby, M., Carroll, M., Daniels,T., and Saynor, Z. (2020 - in press) Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis. Redox Biology
- Ward, T., Evans, R., Lindley, M.R., Singh, S. and Steiner, M. (2020 - accepted). Change in V̇O2peak in response to aerobic exercise training and the relationship with exercise prescription in people with COPD: A systematic review and meta-analysis. Chest.
- Liam M Heaney, L.M., Kang, S., Turner, M.A., Lindley, M.R. and Thomas, C.L.P.(2020 – accepted) Metabolomic study of the exhaled breath of swimmers: evidence for alternative elimination profiles of disinfection by-products and potential markers of airway responses to chlorinated water exposure. Indoor Air
- McMurchie, B., Kelly, P., Reynolds, J., Lindley, M.R., King, R. and Torrens, G. (2020) Dietary omega-3 supplementation causes rapid, reversible changes to dark adaptation ability. https://chemrxiv.org/articles/Shedding_Light_on_the_Effect_of_Fish_Oil_Supplementation_on_Dark_Adaptation_Capabilities/11302613/1
- Steel, R.P., Hussey, B.C.L., Mastana, S.S., Lindley, M.R. and Taylor, I.M. (2020) Health-Related Motivational and Behavioral Processes Associated with DNA Methylation of Tumor Necrosis Factor Gene. Target: Health Psychology. Jan;39(1):68-76. https://psycnet.apa.org/doiLanding?doi=10.1037%2Fhea0000795
- Rosenthal, K, Turner, M., Lindley, M.R. and Hunsucker, E. (2019) Breath selection methods for compact mass spectrometry breath analysis. Journal of Breath Research. Sep 30;13(4):046013 https://iopscience.iop.org/article/10.1088/1752-7163/ab34d4
- Wadley A.J., Keane G., Cullen T., Wilson L., Vautrinot J., Davies M., Hussey B., Hunter DJ., Mastana S., Holliday A., Petersen S., Bishop N.C., Lindley M.R., & Coles S.J. (2019) Characterisation of extracellular antioxidant enzyme concentrations in response to exercise in humans. Journal of Applied Physiology. Sep 1;127(3):858-866 https://www.physiology.org/doi/full/10.1152/japplphysiol.00340.2019
- Youdell, D and Lindley, M.R. (In press). Social Theory, Biological Sciences and the Sociology of Knowledge in Education In: Andrew Brown & Emma Wisby (Eds) Knowledge, Policy and Practice: the struggle for social justice in education, London UCL IOE Press.
- Hunter, D.J. James, L., Hussesy, B., Wadley, A.J., Lindley, M.R. and Mastana, S.S. (2019) Impact of aerobic exercise on fatty acid supplementation on global and gene-specific DNA methylation. Epigenetics. 14:3, 294-309. https://www.tandfonline.com/doi/full/10.1080/15592294.2019.1582276
- Capel. N. J., Lindley, M. R., Pritchard, G. J., Kimber, M. C. (2019) Indium-mediated 2- Oxonia Cope rearrangement of 1,4-dienols to 1,3-dienols. ACS Omega 4, 785. https://pubs.acs.org/doi/10.1021/acsomega.8b03118#