Health
Human health covers a wide number of disciplines in chemistry this is also the case and research spans across all of the traditional disciplines. This ranges from analytical breath analysis to synthetic chemistry and synthetic methodology projects.
Funding in this stream comes from a variety of funders, for example the recently funded NeuChip project funded by the EU.
Synthesis and Bioorganic Cluster
Dr Stephen Butler
Senior Lecturer in Chemistry at the Life Sciences Interface
Areas of interest
Anion Receptors and Imaging Probes; Macromolecular MRI Contrast Agents; Design and synthesis of luminescent host molecules
Recent Publication from the Butler Group:
A simple, robust, universal assay for real-time enzyme monitoring by signalling changes in nucleoside phosphate anion concentration using a europium(III)-based anion receptor
S. H. Hewitt, R. Ali, R. Mailhot, C. R. Antonen, C. A. Dodson and S. J. Butler,
Chem. Sci., 2019, 10, 5373-5381.
Free institutional repository version download link
Professor Andrei Malkov
Professor in Organic Chemistry
Areas of interest
Asymmetric organocatalysis; Catalytic functionalization of C-H bonds; Total synthesis of bioactive natural products; Electrochemical synthesis; Photovoltaics: solution processing of semiconductor thin films.
Recent Publication from the Malkov Group:
Optimization of Catalyst Structure for Asymmetric Propargylation of Aldehydes with Allenyltrichlorosilane
Vaganov, V.Yu., Fukazawa, Y., Kondratyev, N.S., Shipilovskikh, A.A., Wheeler, S.E., Rubtsov, A.E.*, Malkov, A.V.*
Adv. Synth. Catal., 2020, 362, 5467-5474
Free institutional repository version download link
Dr Marc Kimber
Senior Lecturer in Organic Chemistry
Areas of interest
Use of singlet O2 in the development of new synthetic transformationsï total synthesis of natural products and metabolites of biological relevance; rationale design and synthesis chiral cleft molecules.
Recent Publication from the Kimber Group:
Total Synthesis of the Tetrasubstituted Furan Fatty acid Metabolite CeDFP via Au-Catalysed Intermolecular Alkyne Hydroarylation.
Wang, Y.; Pritchard, G. J.; *Kimber, M. C.
Free institutional repository version download link
Dr Gareth Pritchard
Senior Lecturer in Organic Chemistry
Areas of interest
Palladium Catalysed Reactions of Vinylcycloproanes; biosynthetic pathways towards furan fatty acids.
Recent Publication from the Pritchard Group:
A biosynthetically inspired route to substituted furans using the Appel reaction: total synthesis of the furan fatty acid F5.
Lee, R. J.; Lindley, M. R.; *Pritchard, G. P.; *Kimber, M.C.
Chem. Commun. 2017, 53, 6327-6330.
Free institutional repository version download link
Dr George Weaver
Senior Lecturer in Organic Chemistry
Areas of interest
SNAr reactions of perfluorarenes ï Smiles and Truce-Smiles rearrangements ï Reactions of strained heterocyclic systems ï Nitro compounds as building blocks.
Recent Publication from the Weaver Group:
The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines
W J.Robinson, A. E.Taylor S. Lauga-Camia, G. W.Weaver, R. R.J.Arrooc, M. Kaiser, S. Gul, M. Kuzikov, B. Ellinger, K. Singh, T. Schirmeister, A. Botana, C. Eurtivong, A. S.Bhambra Eur. J. Med. Chem. 2021, 209, 112871.
Dr Paul Roach
Senior Lecturer in Biomaterials and Interface Science
Areas of interest
Micro-/nano-fabrication; Designer biomaterials; Tissue Engineering; Neural Engineering.
Recent Publication from the Roach Group:
A targeted near-infrared nanoprobe for deep-tissue penetration and imaging of prostate cancer
M. A. Krishnan, K. Yadav, P. Roach, V. Chelvam
Biomater. Sci. 2021, 9, 2295-2312
Free institutional repository version download link
Dr Brian Cousins
Senior Lecturer in Biomaterials & Nanoscience
Areas of interest
Novel coatings systems; Biomimetic tissue-implant interfaces; Polymeric biomaterials; Controlled release systems; Nanomaterials (Colloids); Electroactive materials; Cell-nanomaterial interactions ï Chemical and biological sensing.
Recent Publication from the Cousins Group:
Gold nanoparticle interactions in human blood: a model evaluation
N. Ajdari, C. Vyas, S. L. Bogan, B. A. Lwaleed, B. G. Cousins Nanomedicine 2017, 13, 1531-1542.
Dr Felix Plasser
Lecturer in Physical Chemistry
Areas of interest
Computational Photochemistry; Quantum chemical method development
Recent Publication from the Plasser Group:
Orbital-free photophysical descriptors to predict directional excitations in metal-based photosensitizers
Analytical Cluster
Professor Paul Thomas
Professor of Analytical Science
Areas of interest
Analysis of Volatile Organic Compounds
Recent Publication from the Thomas Group:
Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry - a feasibility study
Ruszkiewicz, D, Sanders, D, O'Brien, R, Hempel, F, Reed, M, Riepe, A, Bailie, K, Brodrick, E, Darnley, K, Ellerkmann, R, Mueller, O, Skarysz, A, Truss, M, Wortelmann, T, Yordanov, S, Thomas, P, Schaaf, B, Eddleston, M
Dr Matthew Turner
Lecturer in Analytical Science
Areas of interest
volatile organic compounds; novel inlet sources for mass spectrometers; application of metabolomics.
Recent Publication from the Turner Group:
Combined hydrophilic interaction liquid chromatography-scanning field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry for untargeted metabolomics
K. M. Szykuła, J. Meurs, M. A. Turner, C. S. Creaser, J. C. Reynolds
Analytical and Bioanalytical Chemistry 2019, 411, 6309-6317.
Dr Amy Managh
Lecturer
Areas of interest
Single cell analysis; Bio-imaging ï Inductively coupled plasma – mass spectrometry (ICP-MS); Laser ablation ï Nano liquid chromatography
Recent Publication from the Managh Group:
Exploration of matrix effects in laser ablation inductively coupled plasma mass spectrometry imaging of cisplatin treated tumors.
Greenhalgh, C, Karekla, E, Miles, GJ, Powley, IR, Costa, C, de Jesus, J, Bailey, MJ, Pritchard, C, MacFarlane, M, Pringle, JH, Managh, A
Dr Mark Platt
Senior Lecturer
Areas of interest
Sensors for the detection of microorganisms heavy metal ions and biomarkers; Automated fluidic platforms for monitoring contaminants in food and drink; drug dissolution monitoring and emulsions.
Recent Publication from the Platt Group:
The design and characterization of multifunctional aptamer nanopore sensors
Mayne, LJ, Lin, C-Y, Christie, S, Siwy, ZS, Platt, M