EXPERT COMMENT: “For runners of all abilities, their performance on Sunday will be dictated largely by their physiology” explains endurance running expert.

Expert comment
group of runners running along road

Image credit: Getty Images Pavel1964

On Sunday, thousands of runners will line the streets of London to take on the iconic marathon distance. For the elite runners at the front of the race, the journey will last just over two hours; but for many others, it will take considerably longer.

We spoke to Dr Richard Blagrove, an expert in the physiology of endurance running, who explained why your physiology will drive your performance, what happens to your body across the 26.2 miles, and the importance of pacing and developing a varied training programme.

What makes a good marathon runner?

“For many years, sports scientists have been able to predict marathon performance with reasonable accuracy by looking at three key physiological factors: a runner’s maximum aerobic capacity (known as ‘VO₂max’), the proportion of that capacity they access at marathon pace, and how efficiently they run.

“More recently, our research at Loughborough University has shown that a fourth factor - known as ‘durability’ - may be just as important, if not more so, than these three classic determinants of performance.”

What is durability and why is it important?

“Durability describes how well your body can maintain its normal physiological performance as the race progresses, compared with when you are fresh. It helps explain why runners feel comfortable early on, only to struggle in the final 10 miles of events like the London Marathon.

“Our research shows that highly trained runners experience only small declines in aerobic capacity and can maintain their running efficiency even after two hours at marathon pace. As a result, runners with greater durability can hold their speed for longer, and sometimes even accelerate towards the finish, while those with worse durability face the often-unavoidable slowdown in the second half of the race.”

What happens to your body across 26.2 miles?

“A runner’s physiology changes during a marathon for several reasons. Carbohydrate stores in the most economical muscle fibres start to run low, so the body recruits less efficient fibres that cost more energy to use.

“Fatigue also subtly alters running technique, shifting work away from the ankle and reducing the natural ‘spring’ in the legs, which makes each stride more demanding. At the same time, the nervous system works harder to activate tired muscles, further increasing energy expenditure.

“The body is forced to rely more on fat stores, which requires more oxygen than carbohydrate to produce the same energy. Together, these gradual changes make holding the same pace increasingly difficult as the miles tick by.”

Pacing can have a huge impact

"Crucially, the physiological effects that cause runners to slow down in a marathon start earlier than most realise. Our research shows that, particularly when starting too fast, running efficiency can decline after around an hour of marathon pace, which for many is well before halfway. So, a pacing strategy that tries to ‘bank some time’ in the early stages is not very sensible!"

Can runners improve their durability?

“The good news is that durability can be improved, even during the marathon itself. Runners who build higher weekly mileage, do regular long runs, and include strength training tend to hold their efficiency better. Their bodies slow down more gradually, allowing them to maintain their performance deeper into the marathon.

“Carbohydrate availability is crucial for durability because it fuels the most efficient muscles even over long distances. That’s why loading up on carbohydrates before the race, and topping them up regularly during the marathon, is essential.

“Runners setting off through the streets of London on Sunday should be aware that efficiency deteriorates earlier than they might expect, but those who pace smartly and fuel well with carbohydrates are more likely to hold their pace and achieve their goal time.”

ENDS

For further comments or interview requests with Dr Richard Blagrove, please email the PR team or call 01509 222224.

 

Notes for editors

Press release reference number: 26/80

Loughborough is one of the country’s leading universities, with an international reputation for research that matters, excellence in teaching, strong links with industry, and unrivalled achievement in sport and its underpinning academic disciplines. 

It has been awarded five stars in the independent QS Stars university rating scheme and named the best university in the world for sports-related subjects in the 2026 QS World University Rankings – the tenth year running. 

Loughborough has been ranked seventh in the Complete University Guide 2026 – out of 130 institutions. This milestone marks a decade in the top ten for Loughborough – a feat shared only by the universities of Oxford, Cambridge, LSE, St Andrews, Durham and Imperial. 

Loughborough was also named University of the Year for Sport in the Times and Sunday Times Good University Guide 2025 - the fourth time it has been awarded the prestigious title. 

In the Research Excellence Framework (REF) 2021 over 90% of its research was rated as ‘world-leading’ or ‘internationally-excellent’. In recognition of its contribution to the sector, Loughborough has been awarded eight Queen Elizabeth Prizes for Higher and Further Education. 

The Loughborough University London campus is based on the Queen Elizabeth Olympic Park and offers postgraduate and executive-level education, as well as research and enterprise opportunities. It is home to influential thought leaders, pioneering researchers and creative innovators who provide students with the highest quality of teaching and the very latest in modern thinking.