Chemical Engineering

Staff

Dr Huaiyu Yang

Photo of Dr Huaiyu Yang

Lecturer

Dr Huaiyu Yang is Lecturer in Biocrystalliation in the Department of Chemical Engineering. His research is always multi-disciplinary, including; biopharmaceuticals crystallisation; downstream manufacturing; crystallisation of small organic molecules; interface phenomena; nanotechnologies; and; stable and unstable phase diagrams. Before he joined Loughborough as a lecturer, he spent his years in Tianjin University, KTH Royal Institute of Technology, Strathclyde University and Imperial College London for undergraduate study, PhD and postdoc research.

  • 2018.05 –     Lecturer, Loughborough University, Loughborough, UK
  • 2016–2018   Research Associate, Imperial College London, London, UK
  • 2013–2016   Research Associate, University of Strathclyde, Glasgow, UK
  • 2008–2013   Ph.D Degree, KTH Royal Institute of Technology, Stockholm, Sweden
  • 2002–2008   Bachelor & Master’s Degrees, Tianjin University, China

LinkedIn: https://www.linkedin.com/in/huaiyu-yang-54044723/

Follow Huaiyu on Twitter:  @yanghuaiyu

My research ranges from small organic molecules to large biomolecules, from fundamental nucleation theory, to pharmaceutical industrial projects, and from molecular interations, to scaling up and continuous crystallisation.

Area 1: Biocrystallisation in Downstream Separation Process

Fast developments in the upstream production of biopharmaceuticals, drive the downstream separations (DSB) of biopharmaceuticals as a bottleneck for the whole bioprogress. Crystallisation of proteins, including biopharmaceuticals, is a potentially feasible biotechnology in downstream bioseparation for purification and isolation. My research try to develop new generation of platform for biocrystallisation, and the intergration between biocrystallisation and other biotechnologies to overcome the barriers in the DSP. 

Area 2: Nucleation and Crystallisation on interfaces between solid, liquid (liquid-liquid) and gas phases

My research try to demonstrated how the interface can be engineered to control crystallisation of biopharmaceuticals and polymorphs of small molecular pharmaceuticals. The designed and engineered surfaces, between between solid, liquid (liquid-liquid) and gas phases, been applied to control the (bio)crystallisation process.

Area 3: Cell in vivo crystallisation

My research try to find out suitable environments to generate in vivo crystals and environments of growing bigger protein or biomedicine crystals, and by apply different biotechnologies to smartly connecting these stages. 

Area 4: Nanodrop crystallisation

My interest is to generate nano-crystal by nano-drop or nano-devices, to stabilize of nano-size organic or protein crystals by nano-technologies or biotechnologies, to find the applications of nanoparticles with nano-biomedicine in smart drug delivery.

Fellow of the Higher Education Academy

Peer-reviewed papers

1.   Yang H., Belviso B.D., Li X., etc. Caliandro R.*, Heng J.*. Optimization of Vapor Diffusion Conditions for Anti-CD20 Crystallization and Scale-Up to Meso Batch, Crystals 9, 230

2.   Yu, Q.; Pu, J.; Qi, M.; Yang, H.* (2019) Jumping into Metastable 1: 1 Urea-Succinic Acid Cocrystal Zone by Freeze-Drying,Crystal Growth & Design 19, 1505−1508.

3.   Yang, H.; Peczulis, P.; Chen, W.; Heng, J.* (2019) Development and Workflow of a Continuous Protein Crystallization Process A Case of Lysozyme, Crystal Growth & Design 19, 983-991.

4.   Yang, H.; Peczulis, P.; Inguva, P.; Li, X.; Heng, J. (2018) Continuous Protein Crystallisation Platform and Process: Case of Lysozyme, Chemical Engineering Research and Design 136, 529-535 (Front Cover Article)

5.   Yang, H.; Zhang F. Wu, H.;* (2018)Review on Life Cycle of Parabens: Synthesis, Degradation, Characterization and Safety Analysis, Current Organic Chemistry 22, 769-779.

6.   Yang, H.; Song C.; Lim Y.; Chen, W.; Heng, J.*, (2017) Selective Crystallisation of Carbamazepine Polymorphs on Differing Surface Properties, CrystEngComm 19, 6573-6578 (Front Cover Article)

7.   Yang, H.*; Florence, A.; (2017) Relating induction time and metastable zone width, CrystEngComm 19, 3966-3978

8.   Yang, H.; Yu, X. ; Raval, V. ; Makkawi, Y.; Florence, A.*; (2016) The effect of oscillatory flow on nucleation kinetics of butyl paraben. Crystal Growth & Design 16, 875-886.

9.   Bhardwaj, R.; Yang, H.;Florence, A.*; (2016) Crystal structure of the co-crystal butylparaben–isonicotinamide (1/1)." Acta Crystallographica Section E: Crystallographic Communications 72, 53-55.

10. Yang, H.*; (2015) Relation between Metastable Zone Width and Induction Time of Butyl Paraben in Ethanol. CrystEngComm 17, 577-586.

11. Yang, H.*;Rasmuson, Å., (2015) Phase equilibrium and mechanisms of crystallization in liquid-liquid phase separating system. Fluid Phase Equilibria 385, 120-128.

12. Yang, H.*, (2015) Reply to the "Comment on 'Relation between metastable zone width and induction time of butyl paraben in ethanol'" by L.-D. Shiau,. CrystEngComm.17, 4405-4407.

13. Yang, H.;Michael, S.; Jacek Z.; Rasmuson, Å.*, (2014) Influence of solvent and solid-state structure on nucleation of parabens. Crystal Growth & Design 14, 3890-3902.

14. Yang, H.; Chen H.; Rasmuson, Å.*, (2014) Sandwich crystals of butyl paraben. CrystEngComm 16, 8863-8873.

15. Yang, H.*;Rasmuson, Å., (2014) Ternary phase diagrams of ethyl paraben and propyl paraben in ethanol aqueous solvents. Fluid Phase Equilibria376, 69-75.

16. Yang, H.; Rasmuson, Å.*, (2013) Nucleation of butyl paraben in different solvents. Crystal Growth & Design13, 4226-4238.

17. Yang, H.; Rasmuson, Å.*, (2012) Investigation of batch cooling crystallization in a Liquid–Liquid separating system by PAT. Organic Process Research & Development16, 1212-1224

18. Yang, H.; Thati, J.; Rasmuson, Å.*, (2012) Thermodynamics of molecular solids in organic solvents. The Journal of Chemical Thermodynamic48, 150-159.

19. Yang, H.; Rasmuson, Å.*, (2010) Solubility of butyl paraben in methanol, ethanol, propanol, ethyl acetate, acetone, and acetonitrile. Journal of Chemical & Engineering Data55, 5091-5093.

20. Dang, L.; Yang, H.;Black S.; Wei H.*;(2009) The effect of temperature and solvent composition on transformation of β-to α-Glycine as monitored in situ by FBRM and PVM. Organic Process Research & Development13, 1301-1306.

 

Book chapters

  1. Yang, H.; H. ter Horst, J.*, (2017) Crystal Nucleation of Small Organic Molecules in New Perspectives on Mineral Nucleation and Growth, Springer, ISBN: 978-3-319-45667-6 

Presentations                                                                                   

  1. Yang, H.; Heng, J.; (2017) Poster presentation, Seeding and Continuous crystallization of Antibody Cd20. 253rd ACS National Meeting & Exposition, San Francisco, USA
  2. Yang, H.; Heng, J.; (2016) Oral presentation, Protein Crystallization, International Conference of Chemical Engineering and Industrial Biotechnology, Melaka, Malaysia
  3. Yang, H.; (2016) Invited oral presentation, Nucleation and Crystallization of Butyl Paraben, Tianjin University of Technology, Tianjin, China
  4. Yang, H.; Florence, A., (2016) Poster presentation, Nucleation, shear rate and size distribution of cluster, British Association for Crystal Growth, Leeds, UK
  5. Yang, H.; Florence, A., (2016) Oral presentation, Relation of Shear rate and Nucleation, Asian Crystallization Technology Symposium 2016, Tianjin, China
  6. Yang, H.; Florence, A., (2015) Poster presentation, Shear rate and Nucleation in oscillation fluid crystallizer, European Conference on Crystal Growth, Bologna, Italy
  7. Yang, H.; H. ter Horst; J Florence, A., (2015) Poster presentation, Metastable zone width with complex cooling profiles, CMAC open day, Glasgow, UK
  8. Yang, H.; Florence, A., (2015) Oral presentation, Relation between metastable zone width and induction time in nucleation, British Association for Crystal Growth, London, UK
  9. Perciballi, F.; Yang, H.; Florence, A., (2014) Poster presentation (Best Poster Award, 2/50), Agglomeration of ibuprofen in ethanol and water liquid - liquid phase separation, British Association for Crystal Growth, Leeds, UK
  10. Yang, H.; Rasmuson Å., (2011) Poster presentation, Nucleation of butyl paraben, propyl paraben and ethyl paraben in ethanol, ethyl acetate and acetone, British Association for Crystal Growth, University College London, London, UK

Research Gate: https://www.researchgate.net/profile/Huaiyu_Yang

  • Imperial College London
  • RMIT University
  • Tianjin University
  • Strathclyde University
  • Tsinghua University
  • Sun yat-sen University
  • KTH Royal Institute of Technology
  • UCL
  • South China University of Technology
  • Stanford University

A EPSRC funded Research Associate position in biotechnology, biochemical engineering, biomanufacturing and biocrystallization is available within the Department of Chemical Engineering, associated with The Centre for Biological Engineering (CBE), at Loughborough University. The successful candidate will work on an ambitious EPSRC project, Regenerative BioCrystallisation.

For further information, visit:

https://www.jobs.ac.uk/job/BSI330/research-associate-in-cell-culture-and-protein-production

For applying, visit:

https://vacancies.lboro.ac.uk/tlive_webrecruitment/wrd/run/ETREC107GF.open?VACANCY_ID=667844FjtM&WVID=5913100PrZ&LANG=USA

PhD studentships are open to all students. Scholarships for UK/EU provides tuition fees at UK/EU rate and a stipend to cover living expenses.  Scholarships for International (non EU) students only cover the cost of the International tuition fees.

You are also encouraged to look for other funding sources. 

UK-China PhD Placement Programme (Chinese applicants should apply via the China Scholarship Council). 

Applications from students interested in chemical engineering, biochemical engineering, pharmaceuticals, particle technology, materials chemistry, materials science, or other relevant subjects are particularly encouraged. Please send your CV and a cover letter as attachments to Dr Huaiyu Yang (h.yang3@lboro.ac.uk). Candidates will be considered until the position is filled.