Chemical Engineering

Staff

Dr Brahim Benyahia MEng, PhD, AMIChemE

Photo of Dr Brahim Benyahia

Senior Lecturer in Chemical Engineering

PGT Programme Director

Background

Brahim Benyahia graduated with an MEng ("Diplôme d'Ingénieur") in Chemical Engineering from the National Polytechnic School, Algeria. In December 2009, He completed a PhD in Chemical Engineering, at the ENSIC (Engineering School of Chemical Industries) France, then moved for a position of postdoc associate to Massachusetts Institute of Technology (MIT) USA, where he focused for 2.5 years on the development of the first end-to-end integrated continuous pharmaceutical manufacturing platform (a $65 M Novartis-MIT project). In 2013, Brahim joined Loughborough University as a lecturer in Chemical Engineering and was promoted to Senior Lecture in 2017.

Key Awards

  • Co-investigator on the EPSRC CMAC future manufacturing Research HUB.
  • Co-recipient of the Council for Chemical Research (CCR) Collaboration Award 2014.
  • Contribution Award, MIT, USA (2012).
  • Teaching Award of Chemical Engineering (2015 and 2016).

Outline of main research interests:

  • Continuous pharmaceutical manufacturing and crystallisation.
  • Plant wide modelling, optimisation, control and Quality-by-Design.
  • Global, dynamic and multiobjective optimisation.
  • High fidelity models e.g. practical identifiability, true confidence domains.
  • Model Predictive Control (MPC) and Real Time Optimisation (RTO).
  • Multistep and Integrated flow synthesis e.g. MicroFactory.
  • Sustainable production systems (Life Cycle Assessment and Green Engineering).

Grants and contracts:

  • EPSCRC - Future Continuous Manufacturing and Advanced Crystallisation (CMAC) Research Hub (EP/P006965/1).
  • British Council Newton Research Link - Scale up of bioreactors for the production of pharmaceuticals and food: Towards Quality-by-Design.
  • EPSRC - DTC in Continuous Manufacturing and Crystallisation Training Grant - Multiobjective Model Predictive control of integrated processes.

 

 

Current teaching responsibilities 

  • Chemical Process Control - CGC022 / CGC056
  • Process Safety and Design - CGB001
  • Process Balances - CGA007
  • Clean Chemical Energy and Sustainability - CGD070 / CGP070
  • Process Design Project - CGC038 and CGC001
  • Chemical Product Design - CGD059 / CGP059

Recent publications:

  • BandulasenaPP, M.V., VladisavljevićP, G.T., Odunmbaku, O.G., Benyahia, B. (2017). Continuous synthesis of PVP stabilized biocompatible gold nanoparticles with a controlled size using a 3D glass capillary microfluidic device, Chemical Engineering Science, 171, 233-243. doi.org/10.1016/j.cherd.2015.06.039
  • Su, Q., Benyahia, B., Nagy, Z.K., Rielly, C.D., (2015). Mathematical modeling, design, and optimization of a multi-segment multi-addition plug-flow crystallizer for anti-solvent crystallizations. Organic Process Research & Development, 19(12), 1859-1870. DOI: 10.1021/acs.oprd.5b00110.
  • Hreiz, R., Roche, N., Benyahia, B., Latifi, M.A., (2015). Multi-objective optimal control of small-size wastewater treatment plants. Chemical Engineering Research and Design, 102, 345-353. doi.org/10.1016/j.cherd.2015.06.039

Selected publications:

  • Lakerveld, R., Benyahia, B., Heider, P.L., Zhang, H., Wolfe, A., Testa, C., Ogden, S., Hersey, D.R., Mascia, S., Evans, J.M.B., Braatz, D.R., Barton, P. I., (2015). The Application of an Automated Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant. Organic Process Research & Development, 19 (9), 1088-1100. DOI: 10.1021/op500104d.
  • Heider, P.L., Born, S.C., Basak, S., Benyahia, B., Lakerveld, R., Zhang, H., Hogan, R., Buchbinder, L., Wolfe, A., Evans, J.M.B., Jamison, T.F., Jensen, K.F., (2014). Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical. Organic Process Research & Development, 18(3), 402-409. DOI: 10.1021/op400294z.
  • Mascia, S., Heider, P.L., Zhang, H., Lakerveld, R., Benyahia, B., Barton, P.I., Braatz, D.R., Cooney, R.D., Evans, J.M.B., Jamison, T.F., Jensen, K.F., Myerson, A.S., Trout, B.L., (2013). End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation. Angewandte Chemie International Edition, 52(47), 12359-12363. DOI: 10.1002/anie.201305429.
  • Nature Research highlights, 502(274), 2013 (doi:10.1038/502274d).
  • Benyahia, B., Latifi, M.A., Fonteix, C., Pla, F., (2013). Emulsion copolymerization of styrene and butyl acrylate in the presence of a chain transfer agent. Part 2: Parameters estimability and confidence regions. Chemical Engineering Science, 90, 110-118. DOI: 10.1016/j.ces.2012.12.013.
  • Lakerveld, R., Benyahia, B., Braatz, D.R., Barton, P. I., (2013). Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant. 59(10), 3671-3685. DOI: 10.1002/aic.14107.
  • Benyahia, B., Lakerveld, R., Barton, P. I., (2012). A plant-wide dynamic model of a continuous pharmaceutical process. Industrial & Engineering Chemistry Research. 51(47), 15393-15412. DOI: 10.1021/ie3006319.

 View central publications database

 

External Collaborators: 

  • University of Strathclyde
  • Massachusetts Institute of Technology (MIT), USA
  • Laboratory of Reactions and Process Engineering, ENSIC, CNRS, France
  • Universidad Autonoma de Guadalajara, Mexico
  • Rutgers University, USA
  • Technical University of Denmark

External roles and appointments: 

  • Member of the editorial board of "Open Journal of Optimization" and "Process Engineering Journal".
  • Reviewer for more than 10 International journals (e.g. Chemical Engineering Science; Journal of Process Control, Macromolecular Reaction Engineering, Industrial & Engineering Chemistry Research, Crystal Growth & Design,  Process Intensification, Control Engineering Practice).
  • Reviewer for EPSRC and Science Investment Round of the Ministry of Business Innovation and Employment (New Zealand).
  • Several invited international lectures and keynotes (e.g. International workshop on scale up of bioreactors for the production of pharmaceuticals and food: Towards Quality by Design, Mexico, 2016; “Continuous pharmaceutical manufacturing: towards a more flexible and viable industry”. LRGP-CNRS, Nancy, France, 2014).