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The BreathSpec device was used during field trials last year in Finland for a CBRN exercise. Photo by Andrew Weekes

Loughborough research leads to potential Covid-19 diagnosis with a non-invasive breath test that provides almost instant results

Initial findings from a new study led by Loughborough University – published by The Lancet – have shown how Covid-19 can be detected via a non-invasive breath test, providing almost instant results.

Working with partners at the IMSPEX Group - Ion Mobility Spectrometry (IMS) specialists with offices in Wales and Germany - as well as the Royal Infirmary of Edinburgh and Germany’s Klinikum Dortmund Hospital, the consortium’s research team has been able to identify candidate biomarkers present in the breath of someone affected by Covid-19.

Utilising technologies which were originally developed by G.A.S.GmbH as part of the pioneering TOXI-Triage project, the team has demonstrated how these markers or ‘breath signatures’ can be used to rapidly distinguish Covid-19 from other respiratory conditions at point of need,  such as an emergency department, a workplace or a care setting, with no laboratory support.

IMSPEX will be working alongside researchers to help develop and scale such technology. Its BreathSpec device has been a key tool used by researchers in the analysis of volatile organic compounds (VOCs) in human breath.

Ninety-eight patients were recruited for the feasibility study, of whom 31 had Covid-19. Other diagnoses included asthma, exacerbation of asthma and COPD, viral pneumonia, other respiratory tract infections, and cardiac conditions.

To identify and diagnose Covid-19 from the samples the team used Gas Chromatography (GC) – a procedure used for separating and analysing compounds that can be vaporized without decomposition – and Ion Mobility Spectrometry (IMS) – an analytical technique used to separate and identify ionized molecules in the gas phase.

Participants gave a single breath-sample forvolatile organic compounds analysis by GC-IMS. This analysis identified aldehydes (ethanal, octanal), ketones (acetone, butanone), and methanol that discriminated COVID-19 from other conditions.

Speaking about the feasibility study Paul Thomas, Professor of Analytical Science from Loughborough’s Department of Chemistry, said: “We are hugely encouraged by these findings. Employing tried and tested techniques used during the TOXI-Triage project, suggests that Covid-19 may be rapidly distinguished from other respiratory conditions.

“To develop this technique further larger studies are required, together with complementary GC-MS studies, to build on the data collected so far. If shown to be reliable, it offers the possibility for rapid identification or exclusion of Covid-19 in emergency departments or primary care that will protect healthcare staff, improve the management of patients and reduce the spread of Covid-19.”

Speaking about their involvement with the project, Emma Brodrick, Systems Application Manager at IMSPEX said: “Currently the two leading tests for Covid-19 – antigen detection and PCR – both utilise invasive means of taking samples, which can be uncomfortable for the patient and may discourage some from going to get a test they desperately need. We are excited to be working with NHS Trusts in Scotland, Klinikum Dortmund in Germany and Loughborough University to develop a minimally invasive test, that produces results rapidly, indeed in TOXI-Triage our results were within one minute.”

CEO of the IMSPEX Group, Santi Dominguez, added: “The IMSPEX Group is very pleased that our ground-breaking technology has delivered these exciting results. They offer the possibility not only to dramatically improve people’s experience of taking a Covid-19 test but also to play a part in re-starting the economy through rapid screening of large numbers of people, at airports and other transportation hubs, for example.

“What will be needed now will be to rapidly acquire more data to continue to develop the test, and institutional and investor support to scale our manufacturing capability. The IMSPEX Group is looking forward to this challenge.”

The research paper, Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry - a feasibility study, has been published by The Lancet’s EClinicalMedicine journal. It can be viewed here:

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30353-9/fulltext

Notes for editors

Press release reference number: PR 20/172

Loughborough is one of the country’s leading universities, with an international reputation for research that matters, excellence in teaching, strong links with industry, and unrivalled achievement in sport and its underpinning academic disciplines.

It has been awarded five stars in the independent QS Stars university rating scheme, named the best university in the world for sports-related subjects in the 2020 QS World University Rankings and University of the Year by The Times and Sunday Times University Guide 2019.

Loughborough is in the top 10 of every national league table, being ranked 7th in the Guardian University League Table 2021, 5th in the Times and Sunday Times Good University Guide 2020 and 6th in The UK Complete University Guide 2021.

Loughborough is consistently ranked in the top twenty of UK universities in the Times Higher Education’s ‘table of tables’ and is in the top 10 in England for research intensity. In recognition of its contribution to the sector, Loughborough has been awarded seven Queen's Anniversary Prizes.

The Loughborough University London campus is based on the Queen Elizabeth Olympic Park and offers postgraduate and executive-level education, as well as research and enterprise opportunities. It is home to influential thought leaders, pioneering researchers and creative innovators who provide students with the highest quality of teaching and the very latest in modern thinking.

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