School of Sport, Exercise and Health Sciences

Staff

Dr Owen Davies BSc(Hons), PGCE, MRes, PhD

Photo of Dr Owen Davies

Lecturer in Molecular & Regenerative Biomedicine

Owen graduated with an MRes in tissue engineering and regenerative medicine from the University of Manchester. He subsequently completed a PhD at the University of Birmingham that sought to compare the efficacy of stem cells isolated from adipose, bone marrow and dental pulp for the regeneration of mineralised tissue. In 2016 Owen was awarded a competitive EPSRC E-TERM fellowship in collaboration with the University of Birmingham where he worked as an honorary visiting fellow in the School of Chemical Engineering with Professor Liam Grover. During this fellowship Owen established a strong relationship with the clinic, particularly military medicine. In April 2018 he was appointed as a lecturer in Molecular and Regenerative Biomedicine under the Loughborough Excellence 100 scheme.

Owen’s research focuses on defining the cellular and molecular events underlying musculoskeletal development and regeneration. He is particularly interested in stem cell biology and the contribution of nano-sized particles termed extracellular vesicles during the early events underlying bone mineralisation, cellular communication and differentiation. By delineating these complex physiological mechanisms he aims to devise innovative approaches to enhance and monitor tissue regeneration for the treatment of a range of musculoskeletal conditions.

Current research:

  • Defining the cellular and molecular events underlying physiological and pathological (ectopic) bone formation.
  • The role of extracellular vesicles in tissue formation, regeneration and homeostasis.
  • The application of cellular and acellular approaches for musculoskeletal tissue engineering.
  • Stem cell biology and differentiation.
  • Visiting fellow at the School of Chemical Engineering, University of Birmingham
  • Postgraduate certificate in education (PGCE) awarded by the University of Nottingham (2008)
  • Member of the Bone Research Society (BRS), American Society for Bone and Mineral Research (ASBMR), Tissue and Cell Engineering Society (TCES) and Society for Endocrinology
  • Davies OG, et al. (2017). Annexin-enriched osteoblast-derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures. Scientific Reports, DOI: 10.1038/s41598-017-13027-6.
  • Davies OG & Rafiq Q. (2017). Considerations for the bioprocessing, manufacture and translation of extracellular vesicles for therapeutic applications. Cell Gene Therapy Insights. Cell & Gene Therapy Insights, 3(6): 683-694.
  • Hughes E, Davies OG, et al. (2017). Interfacial Mineral fusion and tubule entanglement as a means to harden a bone augmentation material. Advanced Healthcare Materials. Accepted 20/11/2017.
  • Davies  OG, et al. (2016). Defining the balance   between repair and pathological ossification in skeletal muscle. Frontiers Physiology. doi: 10.3389/fphys.2017.00194.
  • Davies OG, et al. (2016). PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification. Journal of Tissue Engineering and Regenerative Medicine. doi: 10.1002/term.2320.
  • Davies  OG, et al. (2015). Identifying the cellular and molecular  mechanisms  leading  to heterotopic ossification. Calcified Tissue International, 97: 432-44.
  • Davies OG, et al. (2015). Modulation of ectopic ossification in tissue engineered  skeletal  muscle  by  an inflammatory  environment.  Frontiers  in  Endocrinology:  Bone  Research. doi: 10.3389/978-2-88919-659-3.
  • Davies OG, et al. (2015). Isolation of adipose and bone marrow mesenchymal stem cells using CD29 and CD90 modifies their capacity for osteogenic and adipogenic differentiation. Journal of Tissue Engineering, 6: 2041731415592356.
  • Davies OG, et al. (2014). A comparison of the in vitro mineralisation and dentinogenic potential of mesenchymal stem cells derived from adipose tissue, bone marrow and dental pulp. Journal of Bone and Mineral Metabolism, 33: 371-82.
  • Davies OG, et al. (2014). The effects of cryopreservation on cells isolated from adipose, bone marrow and dental pulp. Cryobiology, 69: 342-7.

Book Chapters: