School of Mechanical, Electrical and Manufacturing Engineering

Staff

Dr Sourav Ghosh BE MSc PhD

Photo of Dr Sourav Ghosh

Lecturer in Healthcare Engineering

Background 

Sourav is a mechanical engineer by background, and specialises in applying engineering and physical science principles to solve biosensing problems. The key areas of application include clinical diagnostics, biomanufacturing and environmental monitoring.

Following his PhD at the University of Cambridge, Sourav worked there as a postdoctoral researcher in a €14.3m EU consortium project titled “RAPP-ID - Development of RApid Point-of-Care test Platforms for Infectious Diseases” (2011–13).

Prior to his doctoral research, Sourav worked in the industry in heavy engineering, and energy and utilities sectors for five years and completed his postgraduate studies in biomedical engineering from the University of Oxford.

Qualifications

 

  • PhD in Acoustic Biosensors, University of Cambridge, with Rajiv Gandhi (UK) Foundation Scholarship and Overseas Research Scholarship from Cambridge Trusts (2011)
  • MSc in Biomedical Engineering, University of Oxford, with Sloane Robinson Foundation Scholarship (2007)
  • BE in Mechanical Engineering, Indian Institute of Engineering Science and Technology (2001)

 

Research Interests

Sourav applies multi-disciplinary approaches in solving fundamental and applied problems in rapid and realtime biosensing. He has supervised 7 PhD researchers and 3 Postdoctoral Research Associates in this field. His application areas of interest include the following.

  • Infectious disease and antimicrobial resistance: urinary and respiratory tract, blood, wound and gastro-intestinal infections
  • Chronic disease: dementia, cancer and chronic kidney disease
  • Cell therapy manufacturing
  • Environmental monitoring: air and water

 

Sourav’s team in collaboration with leading national and international groups have pioneered the development of two novel acoustic detection principles.

  • Nonlinear acoustic technique that allows improved transduction sensitivity and specificity in detection of sensor-bound microparticles. This has been successfully applied in rapid phenotypic identification of bacteria and antibiotic susceptibility, measuring DNA hybridization, and characterizing biomolecular interactions between microparticles and the sensor.
  • A new and simpler method for measuring the resonance frequency and dissipation of a resonator using a fixed frequency drive that allows greater signal-to-noise ratio and time resolution. This has been applied in realtime detection of immunoproteins and small molecule biomarkers (~200 Da).

 Copies of a unique nonlinear network analyser implementing the above methods have been explored by their national and international collaborators as a research tool.

Awards and Funding

Key funded projects supervised:

 

As a Principal Investigator or Consortium WP leader

  • 2018 – 20: “Rapid Diagnostic test for Early and Accurate treatment of Urinary Tract Infection (READ-UTI)” (£139,793 from EPSRC Impact Acceleration Award and Higher Education Innovation Fund)
  • 2016–17: “Exploring the feasibility of nonlinear acoustic detection technique for online bioprocess monitoring” (£10,000 from BBSRC BioProNET)
  • 2016–17: “Rapid, Affordable and Accessible Diagnosis of Infection and Drug Resistance - Diarrhoea (RAADIR-D)” (£50,666 from EPSRC Institutional Global Challenge Research Fund)
  • 2013–16: “NOROSENSOR - A real-time monitoring system for airborne norovirus” (£227,194 from EU FP7)

 

As a Co-Investigator

  • 2013-16: EPSRC project “Challenge-led Regenerative Medicine Manufacturing Research” (ECP061/1013) (£409,832)
  • 2015–17: EPSRC project “Tackling Antimicrobial Resistance (AMR): An Interdisciplinary Approach” (EP/M027341/1) (£552,439)

 

Current teaching responsibilities:

  • Statics and Dynamics (WSA101)
  • Healthcare Engineering (WSC610)
  • Part C and MSc research projects

 

Current administrative responsiblities: 

  • Lead of Mini Centre for Doctoral Training in “Fighting Infectious Disease: Pushing the Boundaries in Diagnostics and Therapeutics”, which has trained 5 PhD students since 2015/16

 

Key Publications

Journal
  • A. Guha, N. Sandström, V. P. Ostanin, W. Wijngaart, D. Klenerman, S. K. Ghosh, "Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive”, Sensors and Actuators B: Chemical, vol. 281, pp. 960-970, 2019
  • C. Granja, N. Sandström, I. Efimov, V. P. Ostanin, W. Wijngaart, D. Klenerman, and S. K. Ghosh, "Characterisation of particle-surface interactions via anharmonic acoustic transduction," Sensors and Actuators B: Chemical, vol. 272, pp. 175-184, 2018
  • S. Swarbrick, I. Efimov, V. P. Ostanin, D. Klenerman, A. Stolzing, and S. K. Ghosh, "Anharmonic acoustic effects during DNA hybridization on an electrochemical quartz crystal resonator," Electrochimica Acta, vol. 269, pp. 526-533, 2018
  • S. K. Ghosh, V. P. Ostanin, C. L. Johnson, C. R. Lowe, and A. A. Seshia, "Probing biomolecular interaction forces using an anharmonic acoustic technique for selective detection of bacterial spores," Biosensors and Bioelectronics, vol. 29 (1), pp. 145-50, 2011
  • S. K. Ghosh, V. P. Ostanin, and A. A. Seshia, "Anharmonic surface interactions for biomolecular screening and characterization," Analytical Chemistry, vol. 83 (2), pp. 549-554, 2011
  • S. K. Ghosh, V. P. Ostanin, and A. A. Seshia, "Anharmonic interaction signals for acoustic detection of analyte," Analytical Chemistry, vol. 82, pp. 3929-35, 2010 (Accelerated article)
Conference 
  • S. Yika, C. Matthews, W. Malalasekera, S. Ghosh (2018). “Improving efficiency of particle binding in a microfluidic sensor”, Biosensors 2018. Miami, US, 12-15 June 2018
  • A. Guha, N. Sandström, V. P. Ostanin, W. V. D Wijngaart, D. Klenerman, S. K. Ghosh, “Measurement of resonant frequency of a quartz crystal oscillator with immensely improved time resolution using a fixed frequency drive”, 19th International Conference on Biosensors and Bioelectronics, 21-22 August 2017, London, UK
  • Granja, C., Sandström N., Efimov I., Ostanin V., van der Wijngaart W., Klenerman D., Ghosh S. (2017). “Quantification of microparticle-bound proteins using the nonlinear acoustic response of a quartz crystal resonator”, 5th International Conference on Bio-Sensing Technology, Riva del Garda, Italy, 7-10 May 2017
  • Leirs, K., Sandström, N., Ladhani, L., Spasic, D., Ostanin, V., Klenerman, D., van der Wijngaart, W., Lammertyn, J., Ghosh, S. (2014). “Rapid ultra-sensitive detection of influenza A nucleoproteins using a microfluidic nonlinear acoustic sensor”, Biosensors 2014, Melbourne, Australia, 27-30 May 2014.
  • S. K. Ghosh, V. P. Ostanin, and A. A. Seshia, "Anharmonic QCM signals for detection of surface-bound species," Biosensors 2010, 26-28 May 2010, Glasgow, UK
  • S. K. Ghosh, V. P. Ostanin, and A. A. Seshia, "Microbead dynamics on Quartz Crystal Microbalance at elevated amplitudes," 2009 IEEE International Ultrasonics Symposium, 19-23 Sep 2009, Rome, pp. 641-4, 2009
Patent
  • S. K. Ghosh, V. P. Ostanin, and A. A. Seshia, “Apparatus and method for detecting target species in an analyte,” International Patent App. No.: PCT/GB2010/051511 (WO/2011/033285)
  • S. K. Ghosh, V. P. Ostanin, and A. A. Seshia, “Method and apparatus for characterising molecules,” International Patent App. No.: PCT/GB2011/052349 (WO/2012/073011)

Key collaborators:

  • University of Cambridge and University of Leicester (UK), Stanford University (US), KTH Royal Institute of Technology and Stockholm University (Sweden), KU Leuven (Belgium), Fraunhofer EMFT Munich (Germany), Translational Health Science and Technology Institute (India)
  • NHS Nottingham Trust UK, Tata Medical Centre (India)

External roles and appointments: