The 29-year-old, who trains on campus, set a new Paralympic record of one minute 48.99 seconds to defend her Rio 2016 title and add another gold to her Tokyo collection.
In difficult conditions inside the National Stadium, it proved to be a British one-two with Kare Adenegan taking silver, and American Alexa Halko claiming third.
After today’s success, Cockroft now has seven Paralympic gold medals to her name and post-race she joked to the media:
"I'm absolutely gutted. I was so close to that world record, I couldn't have got closer if I'd tried.
"I'm really happy with gold but I'm obviously a bit frustrated I couldn't quite squeeze under that time.
"I did that time in Switzerland on the fastest track in the world so to come here and replicate it, I've got to be proud."
Cockroft’s gold is Loughborough’s 21st medal of an incredible Paralympic Games. This includes six golds, six silvers, and nine bronze medals.
Loughborough University has launched a new initiative for those looking to support the future of Para sport on campus. By supporting the Para Sport programme, individuals can make a profound impact to a young person’s life. To find out more and how to donate, click HERE.
For more information on Loughborough and its presence at the Paralympic Games, visit the dedicated website HERE