Dr Lettie Bishop BSc, PhD
Reader in Exercise Immunology
Lettie’s research interests span the effects of exercise on immune cell function and infection risk in elite athletes to the impacts of exercise on immunity, inflammation and infection in the general population and those with specific long-term conditions. She has recently been awarded 3 years of funding from Heart Research UK to look at the acceptability of different exercise programmes for kidney transplant patients, which will also look at immune and inflammatory responses to activity. Lettie is also a key investigator for the lifestyle theme of the NIHR funded Leicester Biomedical Research Centre. Lettie retains her interest in performance sport and collaborates with the English Institute of Sport on joint funded projects aiming to maximise performance health.
Nicolette (Lettie) Bishop completed her first degree in Sport and Exercise Science at the University of Birmingham in 1997 for which she was awarded the C.T.M Davies Prize for Outstanding Academic Achievement.
Following this, Lettie accepted a PhD Scholarship to work with Professor Mike Gleeson investigating nutritional influences on the immune response to exercise. On completion of her PhD in June 2000, Lettie joined Loughborough University as a Research Associate with the Human Muscle Metabolism Research Group.
In September 2000 Lettie became a Lecturer in Exercise Physiology, becoming Senior Lecturer in 2007 and was appointed to her current position in the School as a Reader in Exercise Immunology in December 2014.
Lettie has been PI and Co-I for grant funding of over £2 million and is a collaborator in the Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, co-supervising a study into the benefits of regular exercise in patients with chronic kidney disease (CKD). She has published over 80 peer-reviewed journal articles, editorials, book chapters and review articles in the area of exercise immunology, including as a co-author on the Feb 2011 International Society of Exercise and Immunology Position Statement on Immune function and Exercise. Since July 2013 Lettie has been an Associate Editor for Medicine and Science in Sports and Exercise, with responsibility for manuscript submissions in the area of exercise, immune function and inflammation.
Lettie has developed her research programme from a keen interest in the effects of exercise on immune cell function and infection risk in elite athletes to a sustainable programme of internationally recognised research investigating the impacts of exercise on systemic and mucosal immunity, chronic systemic inflammation and infection in those with specific long-term conditions. Her recent research is investigating the relationships between an active lifestyle and markers of immune function and chronic inflammation in patients with Chronic Kidney Disease with colleagues of the Leicester Kidney Exercise team at University Hospitals Leicester. Their work in this area was highly commended at the Da Vinci Health Technology awards in March 2010 and the Loughborough University Enterprise Awards in 2014 and is part of the Leicester/Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit (BRU). Lettie also has a strong interest in translating knowledge from healthy individuals to populations with impaired immune function and as such is currently investigating novel systemic and mucosal immune markers to assess the impact of physical activity on immune and inflammatory status in healthy adults and those with other chronic conditions associated with impaired immune function and chronic inflammation.
Selected Recent Research Projects and Sources of Funding
• Sept 2016-Sept 2019 (awarded Dec 2015). Heart Research UK. Reducing cardiovascular disease risk in kidney transplant recipients: A three-arm feasibility study to establish the viability of an RCT of moderate and higher intensity exercise. (£148 500, PI)
• Jan 2016-Dec 2020 (awarded October 2015). English Institute of Sport. Factors affecting iron status and hepcidin in elite athletes (£40 000, PI).
• Oct 2015-Sept 2018 (awarded April 2015). Commonwealth Commission PhD Scholarship (Named Primary Supervisor) The impact of exercise on uremic symptoms, quality of life and markers of systemic inflammation in adults with early stage with chronic kidney disease (£90 000 over 3 years)
• Sept 2014-Sept 2015 Yakult Honsha Co Ltd Effects of Yakult on common cold infection and salivary IgA and defensin secretion in endurance athletes (£195 800, Co-I with Prof Mike Gleeson)
- Associate Editor, Medicine and Science and Sports and Exercise (for Exercise, Immune Function and Inflammation manuscript submissions).
- Adjunct Professor, Department of Health and Human Performance, University of Houston, Texas, USA
- Collaborator in National Institute of Health Research (NIHR) funded work in patients with Kidney disease as part of the Leicester-Loughborough Biomedical Research Unit into Diet, Lifestyle and Physical Activity.
- Editorial Advisory Board member, Journal of Sports Sciences (Physiology Section).
- Immunology and Biochemistry consultant, English Institute of Sport.
Selected Invited Conference Keynote and Speaker Presentations
- May 2014 - 'The anti-inflammatory effects of exercise; mechanisms and implications for the prevention of common diseases’. British Society for Rheumatology, Liverpool, UK
- May 2014 - Keynote lecture : ‘Saliva in Exercise Science’. 10th European Symposium on Saliva, Egmond aan Zee, the Netherlands
- May 2013 - 'Infections in the Paralympic athlete: Tools for predicting and preventing ‘ The UK High Performance Conference for Paralympic Sport Science & Sport Medicine, St George’s Park, Burton upon Trent, UKJuly 2012 - ‘Exercise, immune function and infection: issues for Olympic and Paralympic athletes’. International Convention of Science, Education and Medicine in Sport (ICSEMIS), SSEC, Glasgow, UK.
- July 2012 - ‘What can be done to minimise the risks of illness in athletes’? International Convention of Science, Education and Medicine in Sport (ICSEMIS), SSEC, Glasgow, UK.
- April 2012 - 'Exercise and immunity in athletes' European Society of Clinical Microbiology and Infectious Diseases (ESCMID) 22nd ECCMID, London, UK.
- March 2012 - ‘Immunity in athletes’. Nutritionists in Industry Conference, Twickenham, London UK.
- Dungey M, Young HML, Churchward DR, Burton JO, Smith AC and Bishop NC (2017) Regular exercise during haemodialysis promotes an anti-inflammatory leukocyte profile. Clinical Kidney Journal sfx015 doi: 10.1093/ckj/sfx015
- Bermon S, Castell LM, Calder PC, Bishop NC, Blomstrand E, Mooren FC, Krüger K, Kavazis AN, Quindry JC, Senchina DS, Nieman DC, Gleeson M, Pyne DB, Kitic CM, Close GL, Larson-Meyer DE, Marcos A, Meydani SN, Walsh NP, Nagatomi R. (2017) Consensus Statement Immunonutrition and Exercise. Exercise Immunology Review 23:8-50.
- Leicht, C.A, Paulson TAW, Goosey-Tolfrey VL, Bishop NC. (2016) Arm and intensity-matched leg exercise induce similar inflammatory responses. Medicine and Science in Sports and Exercise 48(6), 1161-1168.
- Gleeson M, Bishop NC, Struszczak L. (2016) Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial. Eur J Appl Physiol. 2016 Aug;116(8):1555-63. doi: 10.1007/s00421-016-3415-x.
- Bishop NC, Hayashida H, Clark M, Coombs C, Miller S, Stensel DJ. (2014) Effect of acute and regular exercise on growth hormone secretagogue receptor-1a expression in human lymphocytes, T cell subpopulation and monocytes. Brain Behav Immun, 39, 172-179.
- Viana JL., Kosmadakis, GC, Watson, EL, Bevington, A., Feehally, J, Bishop NC, Smith AC. (2014) Evidence for anti-inflammatory effects of exercise in chronic kidney disease. J Am Soc Nephrol 2014, 25(9):2121-30
- Gleeson, M. & Bishop NC. (2013). URTI in athletes: Are mucosal immunity and cytokine responses key risk factors? Exercise and Sports Science Reviews, 41(3), 148-153.
- Bishop, N. C. (2012). Overcoming microbial hurdles: keeping the Olympics infection-free. Future Microbiology, 7(8), 913-915
- Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. (2011). The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature Rev Immunol, 11(9), 607-615.
- Viana JL., Kosmadakis, G.C, Watson, E L., Bevington, A., Feehally, J., Bishop, NC. Smith AC. (2014) Evidence for anti-inflammatory effects of exercise. Journal of the American Society for Nephrology April 3, 2014, doi:10.1681/ASN.2013070702
- Bishop NC, Hayashida H, Clark M, Coombs C, Miller S, Stensel DJ. (2013) Effect of acute and regular exercise on growth hormone secretagogue receptor-1a expression in human lymphocytes, T cell subpopulation and monocytes. Brain Behaviour and Immunity, pii: S0889-1591(13)00472-8, doi: 10.1016/j.bbi.2013.09.017.
- Gleeson M, Bishop NC, Walsh NP (Eds.) (2013) Exercise Immunology, Abingdon, Oxon: Routledge
- Dungey M, Hull KL, Smith AC, Burton JO, Bishop NC. (2013). Inflammatory factors and exercise in chronic kidney disease. International Journal of Endocrinology, doi:10.1155/2013/569831
- Gleeson M, Bishop NC. (2013). URTI in athletes: Are mucosal immunity and cytokine responses key risk factors? Exercise and Sports Science Reviews, 41(3), 148-153, doi: 10.1097/JES.0b013e3182956ead
- Leicht CA, Goosey-Tolfrey VL, Bishop NC. (2013). Spinal cord injury: Known and possible influences on the immune response to exercise. Exercise Immunology Review19, 146-165.
- Paulson TAW, Goosey-Tolfrey VL, Lenton JP, Leicht CA, Bishop NC. (2013). Spinal cord injury level and the circulating cytokine response to strenuous exercise. Medicine and Science in Sports and Exercise, 45, doi:10.1249/MSS.0b013e31828f9bbb
- Bishop NC. (2012) Overcoming microbial hurdles: Keeping the Olympics infection free. Future Microbiology 7, 913-915, 2012
- Fletcher DK, Bishop NC. (2012) Caffeine ingestion and antigen-stimulated human lymphocyte activation after prolonged cycling. Scandinavian Journal of Medicine and Science in Sports 22(2), 249-258.
- Kosmadakis GC, John SG, Clapp EL, Smith AC, Bevington A, Bishop NC, Viana JL, OwenPJ, McIntyre CW and Feehally J.(2012) Benefits of regular walking exercise in advanced pre-dialysis chronic kidney disease. Nephrology Dialysis Transplantation27(3):997-1004.
- Leicht C, Bishop NC and Goosey-Tolfrey VL. (2011). Mucosal immune responses to treadmill exercise in elite wheelchair athletes. Medicine and Science in Sports and Exercise. 43(8), 1414-1421.
- Fletcher DK, Bishop NC. (2011) Effect of a single and repeated dose of caffeine on antigen-stimulated human natural killer cell CD69 expression after high-intensity intermittent exercise. European Journal of Applied Physiology. 111(7),1329-1339.
- Walsh NP, Gleeson M, Shephard RJ, Gleeson M, Woods JA, Bishop NC, Fleshner M, Green C, Pedersen BK, Hoffman-Goetz L, Rogers CJ, Northoff H, Abbasi A and Simon P. (2011) Position Statement Part One: Immune Function and Exercise.Exercise Immunology Review 17: 6-63.
- Kosmadakis, G. C., Bevington, A., Smith A. C., Clapp, E. L., Viana, J. L., Bishop, NC, Fehally, J. Physical exercise in patients with severe kidney disease. Nephron Clinical Practice 115, 7-16, 2010
- Bishop NC, Walker GJ, Gleeson M, Wallace FA, and Hewitt CRA. (2009) Human T lymphocyte migration towards the supernatants of Human Rhinovirus infected airway epithelial cells: Influence of exercise and carbohydrate intake. Exercise Immunology Review, 15, 42-59.
- Bishop NC and Gleeson M. (2009) Acute and chronic effects of exercise on markers of mucosal immunity. Frontiers in Bioscience, 14(12), 4444-4456.