Professor Colin Creaser
Emeritus Professor of Analytical Chemistry
Colin Creaser was educated in Uganda and in the UK, at Lancing College and the University of Kent, where he received his BSc and PhD degrees. He has held appointments as a postdoctoral researcher at the University of California at Santa Barbara; Senior Scientific Officer at the AEA Harwell laboratory; Senior Lecturer in Analytical Chemistry at the University of East Anglia and Professor of Analytical Chemistry/Head of the Department of Chemistry and Physics/University Associate Dean at Nottingham Trent University. He was appointed Professor of Analytical Chemistry at Loughborough University in the Centre for Analytical Science in 2007 and awarded the title Emeritus Professor in 2017. He is an active member of the British Mass Spectrometry Society (Chair/Vice-Chair, 2013-15; Papers Secretary, 2012-14), and the Royal Society of Chemistry (FRSC; CChem; President of the Analytical Division and Chair of the Analytical Chemistry Trust Fund, 2002-04).
Ion mobility and mass spectrometry
Research is focused on the development and application of ion mobility spectrometry (IMS) and field asymmetric waveform ion mobility spectrometry (FAIMS)/differential mobility spectrometry (DMS) as gas-phase electrophoretic separation techniques combined with mass spectrometry (MS). Structural and trace analysis is carried out using commercial and prototype tandem IMS-MS and FAIMS-MS instrumentation. Of particular interest is the development of miniaturised FAIMS combined with mass spectrometry and tandem DMS-MS configurations.
Ion mobility spectrometry-mass spectrometry is combined with liquid chromatography and ambient ionization/direct analysis techniques, including thermal desorption, extractive electrospray ionization and desorption electrospray ionization. These are applied to the high throughput analysis of biofluids and other complex samples.
Biomarker discovery and validation
Ion mobility/mass spectrometry methods are applied to the targeted and non-targeted discovery and validation of biomarkers - metabolites and proteins that vary in concentration in biofluids (such as saliva, urine and plasma) in response to disease or physiological state. Combining ion mobility spectrometry with mass spectrometry reduces background interferences, increases the number of compounds detected in biofluids and facilitates the separation of isomeric and isobaric compounds not resolved by mass spectrometry alone.
A key area of activity is the development of fast scanning FAIMS combined with high resolution time-of-flight and Orbitrap mass spectrometry for metabolic profiling (metabolomics). Of particular interest is the discovery and validation of biomarkers associated with physiological stress in sport and exercise, and the diagnosis of asthma.
- Member of the Advisory Board of the British Mass Spectrometry Society (2017-)
- Chair/Vice-chair of the British Mass Spectrometry Society (2013-2015). Papers Secretary (2012-2014).
- Trustee of the Analytical Methods Trust (2005-)
- Fellow of the Royal Society of Chemistry (FRSC) and Chartered Chemist (CChem).
- President of the RSC Analytical Division and Chair of the Analytical Chemistry Trust Fund (2002-2004)
- Member of the international Editorial Advisory Board of Current Analytical Chemistry
Colin Creaser: selected publications (since 2012)
- Increasing peak capacity in non-targeted omics applications by combining full scan field asymmetric waveform ion mobility spectrometry with liquid chromatography–mass spectrometry, Arthur, K.L., Turner, M.A., Reynolds, J.C., Creaser, C.S., Analytical Chemistry, 2017, 89, 3452-3459.
- Rapid analysis of anabolic steroid metabolites in urine by combining field asymmetric waveform ion mobility spectrometry with liquid chromatography and mass spectrometry, Arthur, K.L., Turner, M.A., Brailsford, A.D., Kicman, A.T., Cowan, D.A., Reynolds, J.C., Creaser, C.S., Analytical Chemistry, 2017, 89, 7431-7437.
- Development of a UHPLC-MS/MS (SRM) method for the quantitation of endogenous glucagon and dosed GLP-1 from human plasma, Howard, J.W., Kay, R.G., Jones, B., Cegla, J., Tan, T., Bloom, S., Creaser, C.S., Bioanalysis 2017, 9, 733-751.
- Analysis of supramolecular complexes of 3-methylxanthine with field asymmetric waveform ion mobility spectrometry combined with mass spectrometry, Arthur, K.L., Eiceman, G.A., Reynolds, J.C., Creaser, C.S., Journal of the American Society for Mass Spectrometry, 2016, 27, 800-809
- Direct analysis of oil additives by high-field asymmetric waveform ion mobility spectrometry-mass spectrometry combined with electrospray ionization and desorption electrospray ionization, Da Costa, C., Turner, M., Reynolds, J.C., Whitmarsh, S., Lynch, T., Creaser, C.S., Analytical Chemistry, 2016, 88, 2453-2458.
- Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma, Malkar, A., Wilson, E., Harrrison, T., Shaw, D., Creaser, C.S., Analytical Methods, 2016, 8, 5407-5413.
- Analysis of triacetone triperoxide complexes with alkali metal ions by electrospray and extractive electrospray ionisation combined with ion mobility spectrometry and mass spectrometry, Hill, A.R., Edgar, M., Chatzigeorgiou, M., Reynolds, J.C., Kelly, P.F., Creaser, C.S., Europ. J Mass Spectrom., 2015, 21, 265-274.
- Direct determination of urinary creatinine by reactive-thermal desorption-extractive electrospray-ion mobility-tandem mass spectrometry, Devenport, N.A., Blenkhorn, D.J., Weston, D.J., Reynolds, J.C., Creaser, C.S. Anal Chem, 2014, 86, 357-361.
- Metabolic profiling of human saliva before and after induced physiological stress by ultra-high performance liquid chromatography-ion mobility-mass spectrometry, Malkar, A., Devenport, N.A., Martin, H.J., Patel, P., Turner, M.A., Reid, H.J., Sharp, B.L., Thomas, C.L.P., Reynolds, J.C., Creaser, C.S., Watson, P., Maughan, R.J., Metabolomics, 2013, 209, 1192-1201.
- Direct detection of a sulfonate ester genotoxic impurity by atmospheric pressure thermal desorption−extractive electrospray−mass spectrometry, Devenport, N.A., Sealey, L.C., Alruways, F.H., Weston, D.J., Reynolds, J.C., Creaser, C.S., Analytical Chemistry, 2013, 85, 6224-6227.
- Metabolism of norethisterone in the greyhound, Biddle, S.T.B., O'Donnell, A., Houghton, E., Creaser, C.S., Rapid Communications in Mass Spectrometry, 2013, 27, 2229-2238.
- Enhanced performance in the determination of ibuprofen 1-β-O-acyl glucuronide in urine by combining high field asymmetric waveform ion mobility spectrometry with liquid chromatography-time-of-flight mass spectrometry, Smith, R.W., Reynolds, J.C., Creaser, C.S., Toutoungi, D.E., Boyle, B., Bristow, A.W.T., Ray, A., Sage, A., Wilson, I.D., Weston, D.J., J. Chromatogr. A, 2013, 1278, 76-81.
- Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry, Smith, R.W., Reynolds, J.C., Lee, S-L., Creaser, C.S., Analytical Methods, 2013, 5, 3799-3802.
- Structural studies of metal ligand complexes by ion mobility-mass spectrometry, Wright, V.E., Reynolds, J.C., Christie, S.D.R., Creaser, C.S., Castro-Gómez, F., Bo, C., Jurneczko, E., Barran, P., Poulton, A., International Journal of Ion Mobility Spectrometry, 2013, 16, 61-67.
- Enhanced analyte detection using in-source fragmentation of field asymmetric waveform ion mobility spectrometry-selected ions in combination with time-of-flight mass spectrometry, Brown, L.J., Smith, R.W., Toutoungi, D.E., Reynolds, J.C., Bristow, A.W.T, Ray, A., Sage, A., Wilson, I.D., Weston, D.J., Boyle, B., Creaser, C.S. Analytical Chemistry, 2012, 84, 4095-4103.