Chemistry

Department staff

Dr Amy Managh

Photo of Dr Amy Managh

Lecturer

Amy gained her BSc in Chemistry from the University of Leeds in 2009, followed by move to Loughborough University, where she was awarded an MSc in Pharmaceutical Science and Medicinal Chemistry in 2010 and a PhD in Analytical Chemistry in 2015. As part of her PhD, she collaborated with a pan-European consortium (‘The ONE Study’, EU-FP7), which looked at the evaluation of cell based therapies for use in organ transplantation. Amy’s role involved the design of instrumentation and analysis protocols to track these cells on an individual cell basis. She followed this by securing an EPSRC funded Enterprise Fellowship, titled New Technologies for Single Cell Metallomics, which enabled her to commercialise her inventions in laser ablation technology. As part of this, she worked with Electro Scientific Industries to file a patent and to advance the project from proof-of-concept towards a world leading commercial product, the NWR image.

Amy joined the academic staff as a Lecturer in Chemistry in October 2016. Her current research centres on the trace analysis of biological samples, with a strong emphasis on the rapidly emerging field of Metallomics. Metals play a vital role in the proteome and in the development and treatment of diseases; thus their analysis has huge implications for the healthcare industry. Despite this, improvements to the core technology are required before the major impacts, such as the provision of personalised medicine, can be fully realised. Speed and sensitivity are critical requirements, since rapid decisions are often necessary in the clinical setting and sample sizes may be limited. Amy’s work therefore aims to deliver high speed, high sensitivity imaging of metals in biological tissues, which will enable advances across a range of healthcare challenges.

 

  • Single cell analysis
  • Bio-imaging
  • Inductively coupled plasma – mass spectrometry (ICP-MS)
  • Laser ablation
  • Nano liquid chromatography