Human biology is ill-adapted to modern cities – new study

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A new study has found that modern cities are having a huge impact on our health and wellbeing.

Researchers from Loughborough University and the University of Zurich found that rapid industrialisation has reshaped human habitats so dramatically that our biology may no longer be able to keep up.

The paper, published in Biological Reviews, highlights that densely populated, polluted, and industrialised environments are impairing core biological functions essential for survival and reproduction (i.e., the  ‘evolutionary fitness’ of our species).

These include:

  • Reproductive function, including infertility and sperm decline
  • Immune function issues, such as allergies and autoimmune disease
  • Cognitive function problems, including slower development and faster decline
  • Physical function decline, such as reduced strength and endurance

The authors argue that humans may now be living in environments we are not well adapted to and that this mismatch may be undermining our long-term evolutionary fitness.

With global fertility declining and rising chronic disease, and 68 per cent of the world’s population projected to live in cities by 2050, the team behind the research states that the implications are potentially enormous.

Dr Danny Longman, Senior Lecturer in Human Evolutionary Physiology at Loughborough University, explained:

“For most of our evolutionary history, our biology was shaped by natural environments. In just a few generations, industrialisation has rapidly reshaped the world around us - faster than evolution can keep up.

“The Environmental Mismatch Hypothesis suggests that the very environments we have created to support modern life may now be compromising our ability to thrive and even to reproduce.”

Dr Colin Shaw from the University of Zurich added:

“Our findings highlight that exposure to natural environments is not a luxury - it’s a biological necessity. The more we separate ourselves from nature, the more we risk undermining the fundamental systems that keep us healthy, resilient and capable of long-term survival.”

For more information on the team behind the research, visit its dedicated website: www.heepresearchgroup.com/

This article has been published as part of Loughborough University’s PR Environment campaign. Further information on the campaign can be found in the launch press release.

Notes for editors

Press release reference number: 25/165

Loughborough is one of the country’s leading universities, with an international reputation for research that matters, excellence in teaching, strong links with industry, and unrivalled achievement in sport and its underpinning academic disciplines.

It has been awarded five stars in the independent QS Stars university rating scheme and named the best university in the world for sports-related subjects in the 2025 QS World University Rankings – the ninth year running.

Loughborough has been ranked seventh in the Complete University Guide 2026 – out of 130 institutions.

This milestone marks a decade in the top ten for Loughborough – a feat shared only by the universities of Oxford, Cambridge, LSE, St Andrews, Durham and Imperial.

Loughborough was also named University of the Year for Sport in the Times and Sunday Times Good University Guide 2025 - the fourth time it has been awarded the prestigious title.

In the Research Excellence Framework (REF) 2021 over 90% of its research was rated as ‘world-leading’ or ‘internationally-excellent’. In recognition of its contribution to the sector, Loughborough has been awarded seven Queen Elizabeth Prizes for Higher and Further Education.

The Loughborough University London campus is based on the Queen Elizabeth Olympic Park and offers postgraduate and executive-level education, as well as research and enterprise opportunities. It is home to influential thought leaders, pioneering researchers and creative innovators who provide students with the highest quality of teaching and the very latest in modern thinking.