IAS Seminar: Mechanomedicine to improve cancer treatment

IAS Visiting Fellow Dr Andy Tay Kah Ping delivers a seminar on their research:

Mechanical forces regulate cell behaviours and tissue development. 3D biomaterials are elegant systems enabling us to study mechano-control of cancer formation and drug delivery.

My talk consists of three stories, weaved together based on principles in mechanics to improve cancer treatment:

• In the first project, I will describe the use of magnetic hydrogel for magneto-softening and stiffening of extracellular matrix to study transcriptional plasticity in cancer.
• In the second project, I will describe how nanoparticles of different mechanical geometries can be synthesized to enable more targeted drug delivery to solid tumours.
• Finally, I will conclude by describing how dynamic mechanical ‘massage’ applied to solid tumours can be a universal way to improve nanomedicine delivery by transiently increasing endothelial permeability.

Arrivals from 11.45am for a 12pm start. For those joining in-person, lunch will be served after the seminar from 1pm.