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New technique for slicing delicate biopsy samples inspired by industrial method for cutting tough manufacturing materials

A pioneering manufacturing technique developed to slice metal ‘like butter’ has been adapted by scientists at Loughborough University to improve the quality of biopsy and other biological tissue samples.

A microtome cutting machine - a standard tool for producing tissue samples at most hospitals

The innovation is an oscillating tool attached to a standard piece of medical equipment known as a microtome – a cutting machine which prepares ultra-fine tissue slices for observation underneath a microscope.

By adding a vibrating blade, Dr Anish Roy and his team from the Wolfson School of Mechanical, Electrical and Manufacturing Engineering, was able to reduce the pressure needed to cut samples and as a result generate a smoother cut which improved section quality.

The new technique, which produces slices of tissue measuring just five microns – about a tenth of the width of a human hair – will also double the life of the microtome’s blade.

Researchers from Loughborough’s Mechanics of Advanced Materials research group originally developed the method as a way of improving the process of cutting durable manufacturing materials, such as carbon composites and nickel alloys, as used in the automotive industry.

But now the technique has been revised for use in the medical world.

Dr Roy said the increased longevity of the cutting tools would yield significant cost savings in healthcare due to the intrinsic use of the established medical procedure.

He said: “The idea behind the improvement is simple. When a sculpture chisels a piece of stone he doesn’t do it with big swinging blows – he taps away with small strikes to give the artist control and accuracy in cuts.

“The same is true here – we’re just speeding up the number of strikes. Every second, the blade vibrates about 20,000 times which improves cutting quality.

“Our tests also show that with oscillations, a blade typically lasts twice as long when compared to traditional sectioning processes.”

The scientific procedure, known as histopathology, is widely used in the diagnosis of numerous conditions which attack human cells, such as cancer.

Once cut by the microtome, the tissue specimens, encased in wax, are stained to reveal the underlying tissue structures – this is essential to assess diseased tissues from biopsies – with the results forming an important part in the diagnoses of a wide range of conditions.

Extensive trials of the ultrasonic cutting tool have been carried out at CellPath, a specialist medical equipment manufacturer, and partner in the project.

Preliminary clinical trials have also been conducted at St Thomas’ Hospital, in central London, which is looking at the device’s impact on anatomical pathology.

Dr Guy Orchard, laboratory manager at the London hospital, said: “We are testing the new oscillating microtome blade device in the St John’s Histopathology laboratories at St Thomas’.

“Our research will find out if this exciting innovative design concept can reduce costs and improve quality performance within the field of cellular pathology.”

Dr Roy is now looking at ways to manufacture and market the device.

“Future potential of the project is huge,” he said. “After exhaustive clinical trials, the ultrasonic sectioning device can be retrofitted to traditional microtomes, yielding increased volumes of tissue samples processed with reduced blade wear, improving efficiency and ultimately saving people money.”

Dr Roy and Dr Dong Wang, who worked extensively on the project, have submitted the paper, Ultrasonically assisted cutting of bio-tissues in microtomy, to the journal Physics Procedia.
The project was funded by Innovate UK.

To read the full study, visit: https://dspace.lboro.ac.uk/2134/23956

ENDS

Notes for editors

Press release reference number: 17/51

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Loughborough is one of the country’s leading universities, with an international reputation for research that matters, excellence in teaching, strong links with industry, and unrivalled achievement in sport and its underpinning academic disciplines.

It has been awarded five stars in the independent QS Stars university rating scheme, named the best university in the world to study sports-related subjects in the 2017 QS World University Rankings and top in the country for its student experience in the 2016 THE Student Experience Survey.

Loughborough was ranked 4th in the Guardian University League Table 2017 and 7th in The UK Complete University Guide 2017 and was also named Sports University of the Year by The Times and Sunday Times Good University Guide 2017.

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