Programme | CDT Programme Taught Modules

Core and transferable skills "sheep dip" modules
Loughborough:
Induction (2 days)
  • Safe working practices
  • Risk assessment
  • Research methodologies and management (teambuilding).
Translational project brief (1 Day)
  • Presentation/dissemination skills
  • IP and commercial exploitation
Engineering top up (2 days)
  • Basic bio-processing
  • Bio-materials
 Nottingham:
Therapeutic top up (5 days)
  • Tissue engineering principles
  • Scaffold material chemistry
  • Cell culture
  • General principles of embryonic cell culture
  • Mathematical modelling in tissue engineering
  • Overview of the use of animal models in regenerative medicine
 Keele:
Clinical top up (5 days)
  • Anatomy and physiology
  • Linking structure to function
  • Immunology
  • Human disease and genomics
  • Imaging and diagnostics
  • Case studies: problem based learning
  • Surgical theatre visit
Translation skills modules
Stem cell therapy biology and enabling technologies (Keele and Nottingham)
  • Introduction to stem cells
  • Ethics and regulation
  • Embryonic stem cells
  • Cord blood derived stem cells
  • Bone marrow derived adult stem cells
  • Control of differentiation
  • Stem cell targeting
  • Tissue Specific Stem Cells
  • Engineered scaffolds for stem cells
 Cell and tissue bioprocessing (Lboro)
  • Physical, chemical and biological heterogeneity
  • Strategies for scale-up/ out
  • Suspension/attachment cell culture
  • Cell culture automation
  • Culture process optimisation and experimental design
  • Adult stem cell culture
  • Embryonic cell culture
  • 3D culture systems
 Healthcare Technology Assessment (Keele)
  • Clinical Governance, Clinical Audit
  • Economic Evaluation
  • Assessing Clinical Measurement Technologies
  • Randomised Controlled Trials of Therapeutic Technologies
  • Epidemiological Methods
  • Meta-analysis of Published Trials
Clinical needs and applications (Nottingham and Keele)
  • Gene therapy
  • Drug screening
  • Bone engineering
  • Tendon/ligament and cartilage
  • Corneal
  • Liver
  • Neural
  • Skin
  • Vascular
 Industry structure, regulation and Quality Systems (Loughborough and Nottingham)
  • Industry structure
  • Ethics
  • Regulation and quality systems
  • Regulation of pharmaceuticals
  • Regulation of medical devices
  • GLP/ GMP/ GCCP and Validation
  • Influence of regulation on business and innovation strategy
 Therapeutic product realisation (Loughborough and Keele)
  • New product introduction process
  • Stakeholder requirements capture
  • Biomechanical design
  • Reverse engineering of implants
  • Manufacturing processes for implants
  • Regulated production systems
  • Delivery devices and systems
  • Packaging, storage and transport
  • Bio-mimetic approaches
Specialist skills modules
Cell mechanics, surfaces and signalling (Keele and Loughborough)
  • Viscoelasticity of cells
  • Mechanics of cell deformation
  • Mechanotransduction
  • Cell-flow interaction
  • Mechanics of cell adhesion
  • Cell-substrate interaction
  • Surface characterisation
  • Surface manipulation techniques
  • Micro and nano-feature formation
  • Electro-stimulation
 Analytical and imaging technologies (Loughborough, Keele and Nottingham)
  • Imaging and analytical challenges
  • Analytical cytology
  • Direct optical measurement (LASER scanning cytometry, confocal microscopy, OWLS).
  • Non-invasive techniques (MRI, RAMAN).
  • Off-gas analysis (MS, GC-MS, SIFT-MS).
  • Integrated sensing devices.
  • On-line measurement, monitoring and control.
 Cell therapy (Nottingham and Nottingham University hospital)
  • Overview of current cell therapy trials
  • Limbal stem cells in corneal regeneration
  • Mesenchymal stem cells in gut repair and Crohn's disease
  • Stem cell repair of Musculoskeletal tissue
  • Nerve repair and liver re-generation
  • The potential of cell therapies for Alzheimer's and Parkinson's disease
  • GMP cell culture within the NHS
Developmental biology, embryology and embryonic stem cells (Nottingham)
  • Introduction to developmental biology
  • Regulation of embryonic stem cells
  • Derivation of embryonic stem cells
  • Culture of embryonic stem cells
  • Maintenance of pluri-potency
  • Mouse embryonic stem cells
  • Human preimplantation embryo derived stem cells
 Transport phenomena in biological systems (Loughborough)
  • Rheology and physical properties of biological systems
  • Heat, mass, momentum transfer
  • Modelling of multiphase and multi-physics material systems
  • Microfluidics and its modelling
  • Computational techniques for transfer processes
  • Dynamics of cell growth in scaffolds
  • Extracellular matrix secretion
  • Metabolic pathway modelling
 Orthopaedics and rehabilitation (Keele)
  • Introduction to skeleton and joints
  • Posture and locomotion
  • Spinal instrumentation and biomechanics
  • Spasticity management and alteration in gait
  • Mobility and limb prosthesis
  • Anatomy and biomechanics of joints
  • Robotics and computer aided surgery
  • Fixation and the healing process
  • External fracture fixation systems
  • Joint replacement and implants

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