Tailored magnetic nanotechnology for regenerative medicine: Preparation,characterisation and application
PhD Supervisor(s): Neil Telling, Alicia El-Haj
Contact Email: s.moise@keele.ac.uk
Undergraduate Degree: Bachelor of Technology in Biotechnology (SASTRA University, India)
PhD Summary
To develop a methodology for investigating magnetic nanoparticle (MNP) mediated cellular hyperthermia to control stem cell behaviour. To study different magnetic core materials for their heating efficiency and biocompatibility. To measure localized changes in temperature during hyperthermia using fluorescence based method. To estimate the heating window during hyperthermia, available to control cellular behaviour without triggering cell death.
Cytotoxic effects of different magnetic cores towards primary adult human bone-marrow derived mesenchymal stem cells and osteosarcoma MG63 cell line are assessed via qualitative and quantitative live/dead staining. Magnetic nanoparticle induced hyperthermia studies are performed in a Magnetherm (nanoTherics) device. magnetic properties are measured vie AC magnetic susceptometry.
Skills & Techniques
