Student Profile

Contact Email:paxjr@nottingham.ac.uk

Undergraduate Degree:  BSc Medicinal and Pharmaceutical Chemistry (Loughborough University)

PhD Summary

My PhD project has two work-streams. In the first, as part of a larger project, I am developing a combination therapy (cellular scaffold) as a treatment for an orphan indication of the cornea. This has involved developing biodegradable matrices with suitable chemistry, stiffness and topography to support and stabilise a therapeutic cell population.

Techniques that have been employed to date throughout the first half of this PhD include: Scaffold fabrication (electrospinning and polymer synthesis); Scaffold characterisation (SEM, WCA, FT-IR, and NMR); Cell culture (primary cell extraction and cell-scaffold culture systems); Analysis of biological outputs (cell assay development, qPCR, histology and immunofluorescence)

The second element of the project is focused on identifying and addressing late stage translational issues in cell therapy commercialization. This work has involved the use qualitative methods to identify barriers to the clinical adoption of regenerative medicine therapies in Ophthalmology. Focused on the UK and Canadian healthcare systems, the work has explored how organizational, managerial, and clinical stakeholders currently perceive and react to innovative, disruptive treatments such as cell therapies and regenerative medicines.

 

Publications, Presentations and Awards

Patents

• Barnwell, N, Rose, JB et al (2012) Process (Formula II), GB2012/051037, filed May 2011, issued November 2012.

Publications

• Wilson SL, Sidney, SE, Dunphy, SE, Rose JB, Hopkinson (2013) A Keeping an Eye on Decellularized Corneas: A Review of Methods, Characterization and Applications Journal of Functional Biomaterials. 4, 1 (manuscript accepted)
• Henstock, JR., Rotherham, M., Rose, JB. & El Haj, AJ. (2013). Cyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro. Bone, 53 (2), 468–477.
• Rose, JB. & Williams, DJ. (2012). The UK relative to other single payer-dominated healthcare markets for regenerative medicine therapies. Regenerative medicine, 7 (3), 429–38.

Oral Presentations

• Rose , JB,  Dua, H, El Haj, AJ, Hopkinson, A, Rose FRAJ, Evaluation of electrospun blends of polycaprolactone and gelatin as a material suitable for use in corneal regeneration. 17th Nottingham Eye Symposium (2013), University of Nottingham, UK
• Rose, JB, Dua, H, El Haj, AJ, Hopkinson, A, Rose FRAJ, UK Electrospun blends of polycaprolactone and gelatin for corneal tissue engineering CDT-CC Conference (2013), Loughborough University, UK

Poster Presentations

• Rose, JB, Williams DJ, Adoption Process for Regenerative Medicine Therapies in Ophthalmology(2012),BSRT Regenerative Medicine Symposium, Charite, Germany
• Rose, JB, Williams DJ, Barriers to the Adoption of Regenerative Medicine Therapies in Ophthalmology Limbal Stem Cell Meeting, (2012), Univesity College London, UK
• Rose , JB,  Dua, H, El Haj, AJ, Hopkinson, A, Rose FRAJ, Evaluation of electrospun polycaprolactone and gelatin for use in corneal regeneration treatment, Tissue and Cell Engineering Society Annual Meeting (2012) University of Liverpool, UK
• Rose, JB, Williams DJ, The UK relative to other single payer-dominated healthcare markets for regenerative medicine therapies, BIRAX UK-Israel 1st Regenerative Medicine Conference (2011) Ben-Gurion University, Israel

Awards

• The David Meyer Research Prize 2013 at 17th Nottingham Eye Symposium  – University of Nottingham
• Building Experience and Skill Travel Scholarship 2013 - University of Nottingham
• BIRAX Regenerative Medicine Travel Bursary 2011 – British Council

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