School of Sport, Exercise and Health Sciences

Staff

Jacob Fleming MBioChem

Photo of  Jacob Fleming

Research Assistant in Musculoskeletal Tissue Engineering

Jacob completed his master’s in Molecular and Cell Biology at the University of Oxford (St Hilda’s College) in 2016 before joining Loughborough University to undertake a PhD in models of skeletal muscle. In 2019 Jacob began a short-term RA role for Prof Mark Lewis focused on the development of a model of the myotendinous junction.

Jacob’s current research involves the development of tissue engineered tendons and myotendinous junctions. Within the project there is specific interest in manipulating extracellular matrix composition and utilising mechanical queues to promote correct cell differentiation.

 

  • Tang X, Muhammad H, McLean C, Miotla-Zarebska J, Fleming J, Didangelos A, Önnerfjord P, Leask A, Saklatvala J & Vincent TL (2018) Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ. Ann. Rheum. Dis. 77: 1372–1380