A universal catalytic asymmetric approach to the synthesis of valuable hydroxy enones PhD

Department(s):
Chemistry
Entry requirements:
2:1 +
Part-time:
Not available
Reference number:
CM/MCK-1/2017
Start date:
01 April 2018
UK/EU fees:
TBC
International fees:
TBC
Location:
Loughborough
Application deadline:
31 January 2018

Achievements

5th

in the UK for Chemistry

Guardian University Guide 2018

New

£17m STEMLab facility

2017

Overview

Loughborough University is a top-ten rated university in England for research intensity (REF2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%.

In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career. 

Project detail

The synthesis of biologically important molecules for the development of new medicines is paramount to our health and wellbeing. One of the primary goals in developing new medicines is to synthesise them efficiently and from simple precursors within a laboratory environment. This project will involve the development of an innovative organo-catalytic Korn Blum DeLaMare rearrangement of an achiral endoperoxide to give chiral hydroxy-enone of proven value and applicability.

Hydroxy-enones are an important class of molecules that have been extensively used in the synthesis of many potential new medicines; and endoperoxides are a unique class of molecules that can be easily synthesised in the laboratory by the treatment of cheap commercially available dienes with oxygen, sunlight and a catalyst. Importantly, the chemical reaction to synthesise these valuable hydroxy-enones from endoperoxides, will be of broad applicability and scope, technically simple to complete, and importantly, amenable to scale-up. This later point will be achieved by linking the synthesis of the endoperoxides with this newly developed chemical reaction, and this will be accomplished by using continuous flow technology.

Recent papers by the group on the Korn Blum DeLaMare rearrangement (1) Lee, R. J.; Lindley, M. R.; Pritchard, G. P.; Kimber. M. C. Chem. Commun. 2017, 53, 6327; (2) Priest, J.; Longland, M. R.; Elsegood, M. R. J. Kimber, M. C. J. Org. Chem. 2013, 54, 4098.

Supervisors

Primary supervisor: Dr. Marc C. Kimber

Secondary supervisor: Prof. Andrei Malkov

Find out more

Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in Chemistry.

A relevant Master's degree and / or experience in one or more of the following will be an advantage:

Organic Chemistry
Chemical synthesis
Continous flow chemistry
Organocatalysis

All students must also meet the minimum English Language requirements.

Fees and funding

UK/EU:
TBC
International:
TBC

Tuition fees cover the cost of your teaching, assessment and operating University facilities such as the library, IT equipment and other support services. University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Special arrangements are made for payments by part-time students.

How to apply

All applications should be made online. Under programme name select Chemistry. Please quote reference number: CM/MCK-1/2017

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