How does stem cell transplantation in mice delay brain aging? PhD

Department(s):
Mechanical, Electrical and Manufacturing Engineering
Entry requirements:
2:1 +
Reference number:
AS14092017
Start date:
01 January 2018
UK/EU fees:
TBC
International fees:
TBC
Location:
Loughborough
Application deadline:
01 December 2017

Achievements

3rd

in the UK for research quality

REF 2014

10th

in the UK for Mechanical Engineering

The Complete University Guide 2018

Winner

of 2 Queen's Anniversary Prizes

Overview

Loughborough University is a top-ten rated university in England for research intensity (REF2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%.

In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career. 

Project detail

It has been shown that mesenchymal stem cells (MSC) transplantation into mice or rats improve brain aging. Cognitive decline was delayed and neurogenesis improved, however it is not known what mechanisms are underlying these benefits. To improve MSC therapies targeting the brain, it is important to understand these mechanisms. Tissues of mice transplanted with MSC already exist and need to be analysed. The analysis will include many different techniques including histology, real time PCR and ELISA.

Supervisors

Primary supervisor: Prof Alexandra Stolzing

Secondary supervisor: TBC

Find out more

For further project details email Dr Emiliano Renzi at a.stolzing@lboro.ac.uk or register your interest and ask us a question

Applicants should have, or expect to achieve, at least a 2:1 honours degree (or equivalent) in biology or another relevant area.

A relevant master's degree and / or experience in one or more of the following will be an advantage: biology, cell biology, neurology, biotechnology, biomedical engineering.

Fees and funding

UK/EU:
TBC
International:
TBC

Tuition fees cover the cost of your teaching, assessment and operating University facilities such as the library, IT equipment and other support services. University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Special arrangements are made for payments by part-time students.

This is an open call for candidates who are sponsored or who have their own funding. If you do not have funding, you may still apply, however Institutional funding is not guaranteed. Outstanding candidates (UK/EU/International) without funding will be considered for funding opportunities which may become available in the School.

How to apply

All applications should be made online. Under programme name, select Chemical Engineering (Regenerative Medicine). Please quote reference number: AS14092017

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