Finite element modelling of heart valve deformation and mitral regurgitation after mitraclip implantation PhD

Department(s):
Mechanical, Electrical and Manufacturing Engineering
Entry requirements:
2:1+
Full-time:
3 years
Part-time:
6 years
Reference number:
LG2UF2018
Start date:
01 October 2018
UK/EU fees:
£4,195
International fees:
£20,500
Location:
Loughborough
Application deadline:
09 March 2018

Achievements

3rd

in the UK for research quality

REF 2014

10th

in the UK for Mechanical Engineering

The Complete University Guide 2018

Winner

of 2 Queen's Anniversary Prizes

Overview

Loughborough University is a top-ten rated university in England for research intensity (REF2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%.

In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career. 

Project detail

The mitral valve (MV) is a complex structure regulating forward flow of blood between the left atrium (LA) and left ventricle (LV) of human heart. It has multiple components and complex internal interactions. Multiple disease processes can affect its proper function, for instance, mitral regurgitation (MR). Recently, Mitraclip implantation is widely used as an approach, alternative to conventional open-chest surgery, to treat mitral valve regurgitation in high-risk patients. However, the clip implantation may induce some other problems due to the changed MV biomechanics. So it is important to understand the biomechanical behaviour of MV after mitraclip implantation, such as deformation and stress distribution on the leaflets in MV, for which the research is very limited according to literature. In this project, finite element method will be used to simulate the mechanical deformation and stress distribution of MV. The results will be used for the development of mitraclip.

The candidate will join the vibrant Mechanics of Advanced Materials research group at Loughborough University. Material behaviour of mitral valve leaflets will be collected from literature and used as input for finite element simulations. In addition, fluid-solid interaction will be modelled to evaluate the MR after clip implantation. Simulation results will be compared with in-vitro experimental results in literature. The research outcome will serve as a driving force to boost the development of advanced therapies for heart valve diseases, especially for vulnerable patients such as ageing populations.

Supervisors

Primary supervisor: Liguo Zhao

Secondary supervisor: TBC

Find out more

For further project details email Liguo Zhao or register your interest and ask us a question.

To find out more about the School of Mechanical, Electrical and Manufacturing Engineering, please visit our website.

Further information on the Mechanics and Advanced Materials Loughborough University Research Group can be found here.

Entry requirements

Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in Mechanical Engineering, Biomechanical Engineering, Solid Mechanics, Applied Mathematics, Physics or a related subject. 

A relevant Master’s degree and/or experience in one or more of the following will be an advantage: Mechanical Engineering, Biomechanical Engineering, Solid Mechanics, Applied Mathematics, Physics.

All students must also meet the minimum English Language requirements.

Fees and funding

UK/EU:
£4,195
International:
£20,500

Tuition fees cover the cost of your teaching, assessment and operating University facilities such as the library, IT equipment and other support services. University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Special arrangements are made for payments by part-time students.

This is an open call for candidates who are sponsored or who have their own funding. If you do not have funding, you may still apply, however Institutional funding is not guaranteed. Outstanding candidates (UK/EU/International) without funding will be considered for funding opportunities which may become available in the School.

How to apply

All applications should be made online. Under programme name select Mechanical and Manufacturing Engineering. Please quote reference number: LG2UF2018

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