Antimicrobial Resistance Research

Therapeutics & Diagnostics

Developing cost effective scalable manufacturing processes for bacteriophage amplification and purification

Antibiotic resistance has become an important medical issue because of the increase of anti-microbial resistance (AMR). As it is well known from years, microbes are becoming resistant to antibiotics; in part this is due to poor stewardship of antibiotics together although resistance is inevitable. There is also a pressing need to find new antimicrobial compounds. Phage therapy can be a useful tool to contrast antimicrobic resistant bacteria infections. In this project we are developing scalable manufacturing processes for bacteriophage production against multidrug resistant Staphyococcus aureus, E-coli and C. difficile using Quality-by-Design (QbD) approaches. We aim to develop scalable optimised bioreactor systems yielding high phage titers with batch-to-batch variability under control to achieve target product quality.


Staff: D J Malik; B Beyahia; F Manucuso (PhD Student)