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Volunteers needed for study into novel diabetes drug which helps patients lose weight

Volunteers are needed for a study which looks at new diabetes medication that aids weight loss.

The study will measure how empagliflozin impacts upon people’s appetite and metabolism

Researchers from Loughborough University are working with Leicester Diabetes Centre to examine empagliflozin – a drug which controls blood sugar levels, but which also substantially reduces body weight.

The study is looking for men and post-menopausal women who have type 2 diabetes and who are currently taking the drug metformin or volunteers who use diet and lifestyle to control their diabetes.

The aim of the project, titled SGLT-2 inhibitor Empagliflozin Effects on Appetite and Weight Regulation: A Randomised Double-Blind Placebo-Controlled trial (SEESAW), is to see how empagliflozin impacts upon people’s appetite and metabolism compared with diet-induced weight loss and a placebo.

Loughborough University’s Professor David Stensel and Dr James King are investigators on the project.

Dr King said: “In recent years, we have seen some diabetes medications enter the market which help people lose weight, whereas in the past some drugs actually make people put weight on – which is problematic as being overweight is one of the key problems that causes type 2 diabetes.

“The drug we are looking at, called empagliflozin, is an SGLT2 inhibitor which helps people lose weight by causing the excretion of glucose (energy) in the urine.

“We are investigating how this affects appetite, overall energy balance and various aspects of metabolism.

“Given that the majority of patients with type 2 diabetes are overweight, it’s really useful to have a drug that helps with weight loss.

“Our expertise in Loughborough relates to appetite regulation and energy balance part of the study.”

Empagliflozin is a class of drug called SGLT-2 inhibitors, commonly used to help people with Type 2 diabetes lose weight.

It works by increasing the amount of sugar in the urine, which helps to lower the amount of blood glucose in the body.

Glucose lost in the urine is in the form of calories, and this results in weight loss over a few months of treatment.

However, the weight loss seen in people taking empagliflozin is less than researchers would expect considering the number of calories being lost as glucose in the urine.

It is believed this discrepancy may be due to how the drug affects appetite.

The study, set to take place across 21 months, will provide researchers with a better understanding of why the predicted and observed weight loss is different when taking empagliflozin by measuring appetite regulation.

At 8.9 per cent, the diabetes prevalence rate in Leicestershire is one of the highest in the UK and well above the national average of 6.4 per cent.

Those figures translate to approximately 25,000 people in Leicester with diabetes, with a further 6,000 who have not yet been diagnosed.

Professor Melanie Davies CBE, Professor of Diabetes Medicine at the University of Leicester and Chief Investigator of the study, said: “We already know type 2 diabetes is very closely associated with weight, with over 90 per cent of newly diagnosed people above their ideal weight.

“Losing weight can help people control their condition and further complications which is why we wanted to explore the benefits of empagliflozin and how it might significantly alter people’s health in the long-run.”

For more information about the study or to sign up to take part, email:  LDC.Trials@uhl-tr.nhs.uk or phone 0116 258 6439.

ENDS

Notes for editors

Press release reference number: 17/158

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Loughborough is one of the country’s leading universities, with an international reputation for research that matters, excellence in teaching, strong links with industry, and unrivalled achievement in sport and its underpinning academic disciplines.

It has been awarded five stars in the independent QS Stars university rating scheme, named the best university in the world to study sports-related subjects in the 2017 QS World University Rankings and top in the country for its student experience in the 2016 THE Student Experience Survey.

Loughborough is in the top 10 of every national league table, being ranked 6th in the Guardian University League Table 2018, 7th in the Times and Sunday Times Good University Guide 2018 and 10th in The UK Complete University Guide 2018. It was also named Sports University of the Year by The Times and Sunday Times Good University Guide 2017.

Loughborough is consistently ranked in the top twenty of UK universities in the Times Higher Education’s ‘table of tables’ and is in the top 10 in England for research intensity. In recognition of its contribution to the sector, Loughborough has been awarded seven Queen's Anniversary Prizes.

The Loughborough University London campus is based on the Queen Elizabeth Olympic Park and offers postgraduate and executive-level education, as well as research and enterprise opportunities. It is home to influential thought leaders, pioneering researchers and creative innovators who provide students with the highest quality of teaching and the very latest in modern thinking.

 

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