Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Centre for Biological Engineering

A Preservation and Packaging Platform for Cell and Tissue Based Therapies

Diagrams

This project aimed to create a preservation and packaing platform for cell and tissue based therapies, allowing UK companies to reach the European, North American and other global markets. Traditionally, preservation, storage and transportation solutions for biological entities, mostly protein-based, have involved freezing or freeze drying. However, living cells constitute an essential part of cell therapy applications and there is a real and urgent need for packaging solutions that preserve cell viability and function post transport, and provide ease-of-use to the end-user in clinic.

Key components of a packaging and shipping platform for human cell and tissue based therapies have been demonstrated, in particular the use of mathematical modelling for package design and the effects of temperature and vibration during cold chain shipping of therapeutic cell types. Packaging design mathematical models have been implemented by an industrial partner. Results of the measurement of the effects of vibration experienced by cells in cold chain transportation have been published. This research has identified the requirement to better understand the underlying phenomena affecting cells in liquid suspensions in order to improve the design of transport systems.

Funding bodies

Project dates / duration

July 2008 - December 2011

Project team

Collaborators

Contact

Dr Yang Liu: Y.Liu3@lboro.ac.uk, 01509 227602

Project outputs / results

The sensitivity of human mesenchymal stem cells to vibration and cold storage conditions representative of cold transportation, NI Nikolaev, Y Liu, H Hussein & DJ Williams,
J. R. Soc. Interface 9(75): 2503-2515, 07 Oct 2012 doi: 10.1098/rsif.2012.0271 1742-5662

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EPSRC Doctoral Training Centre Regenerative Medicine logo

State-of-the-art facility

The facility is made up of a suite of Class 2 laboratories for cell growth, a bioelectrical facility and an analytical suite to service all laboratories.

Find out more about the Centre's facilities »