Student Profile

Rebecca Choi

Rebecca Choi

Label-free, non-invasive imaging of live cell attachment

PhD Supervisor(s): Melissa Mather, Virginie Sottile,  Mike Somekh, John Crowe

Univeristy of Nottingham

Contact Email: eexrc3@nottingham.ac.uk

Undergraduate Degree:  MEng in Biochemical Engineering (UCL)

PhD Summary

This project is about developing and applying imaging technologies to characterise cells. The technique will support the manufacturing process of cell based products. The aim is to image living cells non-invasively in their culturing state and to link their adhesion status with their health level.

I am developing a novel portable device that takes pictures of live cells. The device uses a technique called total internal reflection microscopy and the pictures shows how well the cells are adhered onto the surface they are growing on. The system measures and predicts the health status of live cells based on their adhesion profile and is an alternative tool for cell characterisation. 

The skills I have acquired include experienced with culturing Mesenchymal stem cells and neural stem cells along with proficient knowledge in optics and various microscope techniques, practical experience in building and troubleshooting simple microscope systems. I am an advanced beginner at bulk image processing using Matlab, Labview tinkerer for instrumentation control and a skilled user of Microsoft Office.

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