Nicolette Bishop BSc PhD
Senior Lecturer
Contact details
Room: HE.1.17
Phone: +44 (0)1509 226385
Fax: +44 (0)1509 226301
Email: N.C.Bishop@lboro.ac.uk
Biography
Nicolette (Lettie) Bishop completed her first degree in Sport and Exercise Science at the University of Birmingham in 1997 for which she was awarded the C.T.M Davies Prize for Outstanding Academic Achievement. Following this, Lettie accepted a PhD Scholarship to work with Professor Mike Gleeson investigating nutritional influences on the immune response to exercise. On completion of her PhD in June 2000, Lettie joined Loughborough University as a Research Associate with the Human Muscle Metabolism Research Group. In September 2000, Lettie became a Lecturer in Exercise Physiology and in 2007 was appointed to her current position in the School as a Senior Lecturer.
Research and Teaching Interests
Lettie’s research interests lie in the effect that exercise has on immune function and inflammation in healthy individuals and in those with chronic conditions. Most recently she has been investigating the relationships between an active lifestyle and inflammatory mediators on markers of chronic inflammation and immune function in patients with Chronic Kidney Disease with colleagues at University Hospitals of Leicester NHS trust; their work in this area was highly commended at the Da Vinci Health Technology awards in March 2010. Lettie is also investigating the effects of acute exercise and training on immunoendocrine function, markers of inflammation and respiratory infection incidence in elite and recreational athletes with spinal cord injuries in collaboration with Dr Vicky Tolfrey, Director of the Peter Harrison Centre for Disability Sport at Loughborough University. Lettie is also interested in nutritional influences on immune responses to exercise. Lettie’s research is a mixture of both fundamental and applied research and involves a multidisciplinary approach encompassing exercise physiology, biochemistry, immunology and nutrition.
Lettie teaches in this area of exercise and immunology on the MSc Exercise Physiology and MSc Sport and Exercise Nutrition programmes and teaches in the area of exercise physiology on the undergraduate programme.
Selected Publications
Leicht, C.L., Bishop, N.C. & Goosey-Tolfrey, V.T. Mucosal immune responses to treadmill exercise in elite wheelchair athletes. Medicine and Science in Sports Exercise 2011 doi: 10.1249/MSS.0b013e31820ac959
Gleeson M, Bishop N.C., Oliveira M, Tauler P. Daily probiotic (Lactobacillus casei Shirota) reduces infection incidence in athletes. Int J Sport Nutr Exerc Metab 21 55-64, 2011.
Fletcher, D.K., Bishop, N.C. Caffeine ingestion and antigen-stimulated human lymphocyte activation after prolonged cycling. Scandinavian Journal of Medicine and Science in Sports 2010 doi: 10.1111/j.1600-0838.2010.01223.x.
Fletcher, D.K., Bishop, N.C. Effect of a single and repeated dose of caffeine on antigen-stimulated human natural killer cell CD69 expression after high intensity intermittent exercise. European Journal Applied Physiology 2010 doi: 10.1007/s00421-010-1751-9
Kosmadakis, G. C., Bevington, A., Smith A. C., Clapp, E. L., Viana, J. L., Bishop, N. C., Fehally, J. Physical exercise in patients with severe kidney disease. Nephron Clinical Practice 115, 7-16, 2010
Bishop, N.C., & Gleeson, M. Acute and chronic effects of exercise on markers of mucosal immunity. Frontiers in Bioscience, 14(12), 4444-4456, 2009.
Bishop, N.C., Walker, G.J., Gleeson, M., Wallace, F.A., & Hewitt, C.R.A. Human T lymphocyte migration towards the supernatants of Human Rhinovirus infected airway epithelial cells: Influence of exercise and carbohydrate intake. Exercise Immunology Review, 15, 42-59, 2009.
Walker, G.J., Finlay O.J., Griffiths, H., Sylvester, J., Williams, M., Bishop, N.C. Immunoendocrine response to cycling following ingestion of caffeine and carbohydrate Medicine and Science in Sports and Exercise, 39: 1554-1560, 2007, ISSN 0195-9131
Broom, D.R., Stensel, D.J., Bishop, N.C., Burns S.F., Miyashita, M. Exercise induced suppression of acylated ghrelin in humans. Journal of Applied Physiology 102: 2165-2171, 2007, ISSN 8750-7587
Bishop N.C. Exercise and acquired immune function. In: Immune function in Sport and Exercise (edited by M. Gleeson), Edinburgh: Churchill Livingstone Elsevier, 2006 pp. 91-113. ISBN 0 443 10118 3
Bishop, N.C., Walker, G.J., Scanlon, G.A., Richards S.R., Rogers E. Salivary IgA responses to prolonged intensive exercise following caffeine ingestion. Medicine and Science in Sports and Exercise, 38(3), 513-519, 2006, ISSN 0195-9131
Gleeson, M, Bishop N.C. The T cell and NK cell immune response to exercise. Annals of Transplantation 10(4): 43-48, 2006, ISSN 1425-9524
Nieman, D.C., Bishop N.C. Nutritional strategies to counter stress to the immune system in athletes, with special reference to soccer. Journal of Sport Sciences, 24(7), 763-772, 2006, ISSN 0264-0414
Whitham, M., Walker, G.J., Bishop, N.C. Effect of caffeine supplementation on the extracellular heat shock protein 72 response to exercise. Journal of Applied Physiology 101: 1222-1227, 2006, ISSN 8750-7587
Bishop, N.C., Walker, G.J., Bowley, L.A., Evans, K.F., Molyneux K, Wallace F.A., Smith, A.C. Lymphocyte responses to influenza and tetanus toxoid in vitro following intensive exercise and carbohydrate ingestion on consecutive days. Journal of Applied Physiology 99: 1327-1335, 2005, ISSN 8750-7587
You can view a fuller publications list on the University Publications Database.
External Activities
Selected External Research-Related Roles
Invited co-author : International Society of Exercise and Immunology Consensus Statement on immune function and exercise (to be published in 2011).
Invited reviewer for papers submitted to Brain, Behaviour and Immunity, European Journal of Applied Physiology, International Journal of Sports Medicine, International Journal of Sport Nutrition and Exercise Metabolism, Journal of Applied Physiology, Journal of Physiology, Journal of Sports Sciences, Medicine and Science in Sports and Exercise, Sports Medicine
Member of the East Midlands Clinical Exercise Research Group
Selected Invited Conference Keynote and Speaker Presentations
T cell migratory responses to antigens after physical stress. Invited Speaker at the Immunosenescence Symposium, University of Birmingham, April 2010.
Overtraining: effects on the immune system. Invited speaker at the 5th National Orthopaedics and Sports Injuries Conference, London, Nov 2009.
Selected Recent Research Projects and Sources of Funding
Da Vinci Health Technology Awards 2010 (Highly Commended) (with Prof J Feehally, Dr A Smith and Dr R Ferguson) Exercise Training in Chronic Kidney Disease (£2000).
Yakult Honsha Co Ltd 2008 (with Prof M Gleeson) - Effects of a Probiotic Intervention on Infection, Cold Symptom Duration/Severity and Mucosal Immunity in Endurance Athletes. (£70 000 over 6 months, November 2008-May 2009).
GlaxoSmithKline 2006 (with Prof M Gleeson, Dr C Hewitt) - The effects of prolonged exercise and Lucozade Sport on the migration of human T lymphocytes towards the supernatants of respiratory virus infected airway epithelial cells. (£70 000 over 1 year, October 2006-October 2007).
Milk Development Council 2004 (with Prof R Maughan, Prof M Gleeson, Dr S Shirreffs) – Milk and sports nutrition (220 000 over 30 months, April 2004-October 2006).
GlaxoSmithKline 2002 (with Dr A Smith) - Can consuming carbohydrate-electrolyte beverages during high-intensity intermittent exercise minimise the expected suppression of in vitro cell-mediated immune responses to clinically relevant antigens? (£72 000 over 2 years, September 2002-August 2004).