Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Chemistry

Department staff

Professor Colin Creaser

Professor of Analytical Chemistry
Head of the Centre for Analytical Science

Tel +44 (0) 1509 222552

Biography

Colin Creaser was educated in Uganda and in the UK, at Lancing College and the University of Kent, where he received his BSc and PhD degrees. He has held appointments as Postdoctoral Research Fellow at the University of California at Santa Barbara; Senior Scientific Officer at AEA Harwell; Senior Lecturer in Analytical Chemistry at the University of East Anglia and Professor of Analytical Chemistry/Head of the Department of Chemistry and Physics/University Associate Dean (Research & Graduate Studies) at Nottingham Trent University. In 2007, Colin moved to his present appointment at Loughborough as Professor of Analytical Chemistry and Head of the Centre for Analytical Science in the Department of Chemistry.

Research areas

Our research is focused on two related areas of analytical science: mass spectrometry and ion mobility spectrometry. Please follow the links for information on the Creaser Research Group and Selected Publications (including ion mobility publications)

  • Mass Spectrometry. We are researching several areas concerned with the development and application of mass spectrometry and gas-phase ion chemistry using time-of-flight, quadrupole/time-of-flight, combined chromatography-mass spectrometry and ion mobility-mass spectrometry instrumentation.
  • Ion mobility spectrometry. We have pioneered developments and applications of ion mobility spectrometry (IMS) and field asymmetric waveform ion mobility spectrometry (FAIMS) as gas-phase electrophoretic separation techniques. Structural and trace analysis is carried out using commercial and prototype IMS, IMS-MS and FAIMS-MS instrumentation. We have a particular interest in miniaturised, chip-based FAIMS combined with mass spectrometry.

 

We are applying our novel mass spectrometry and ion mobility spectrometry techniques to analytical applications in the following areas:

  • Ambient ionization/direct analysis techniques. The development of high-throughput mass spectrometry and ion mobility-mass spectrometry techniques, based on thermal desorption, desorption electrospray ionization and extractive electrospray ionization, for qualitative and quantitative analysis.
  • Biomarkers. The development of targeted and non-targeted mass spectrometry and ion mobility-mass spectrometry methods for the identification and quantification of biomarkers (metabolites and proteins) that vary in concentration in biofluids (such as saliva, urine and plasma) in response to disease or physiological state.
  • Structural studies by ion mobility spectrometry. The use of ion mobility spectrometry to measure collision cross sections of selected ions, particularly those derived from self-assembled metal-ligand complexes.

 

Collaborators and funders:

Agilent Technologies; Castrol; EPSRC; HFL Sport Science; Institute of Chemical Research of Catalonia (Tarragona); Owlstone Limited; Loughborough University School of School of Sport, Exercise and Health Sciences, University of Strathclyde.

External activities

  • Chair of the British Mass Spectrometry Society (2014-16). Vice-Chair and Papers Secretary (2012-14).
  • Fellow of the Royal Society of Chemistry (FRSC) and Chartered Chemist (CChem).
  • Formerly President of the RSC Analytical Division and Chair of the Analytical Chemistry Trust Fund (2002/04)
  •  Member of the international Editorial Advisory Board of Current Analytical Chemistry
  • Trustee of the Analytical Methods Trust