Chemistry

Department staff

Dr Mark Edgar

Photo of Dr Mark Edgar

Senior Experimental Officer in NMR Spectroscopy

  • BSc University of Liverpool 1988 - 1991 (Organic Chemistry Prize 1990)
  • PhD University of Liverpool 1991 - 1994 (Prof. R. J. Abraham).
  • Post-Doc University of Southampton 1994 - 1996 (Prof. J. W. Emsley).
  • Guest Researcher and Humboldt Research Fellow FU-Berlin 1996 – 1998.
  • Guest Researcher University of Southampton 1998 (Dr. G. S. Attard).
  • Post-Doc University of St Andrews 2000 - 2002(Dr. P. A. Wright).

Nuclear Magnetic Resonance (NMR) Spectroscopy investigations of materials, ranging from small molecules to solids. Computational chemical shift calculations and ab-initio structural calculations.

  • Consultancy and sample analysis for industry.

Selected publications:

“A new paradigm in N-heterocyclic carbenoid ligands”Page PCB, Buckley BR, Christie SDR, Edgar M, Poulton AM, Elsegood MRJ, McKee V JOURNAL OF ORGANOMETALLIC CHEMISTRY 690 (24-25): 6210-6216 DEC 1 2005

“Complementary stereoselective conjugate addition reactions on indolo[2,3-alpha]-quinolizine templates”Allin SM, Khera JS, Thomas CI, Witherington J, Doyle K, Elsegood MRJ, Edgar M TETRAHEDRON LETTERS 47 (12): 1961-1964, 2006

“Complementary routes for the stereoselective synthesis of functionalized benzoquinolizidine targets”Allin, Steven M., Duffy, Liam J., Bulman Page, Philip C., McKee, Vickie, Edgar, Mark, McKenzie, Michael J., Amat, Mercedes, Bassas, Oriol, Santos, Maria M. M., Bosch, Joan TETRAHEDRON LETTERS 47 (32): 5713-5716, 2006

"A novel trisprotonated beta-dialdiminate cryptand  Chin, A; Edgar, M; Harding, CJ,McKee V,Nelson J DALTON TRANSACTIONSIs: 32p 6315-63262009

“The in-situ solid-state NMR spectroscopy investigation of alcoholic lactose suspensions " Crisp, JL; Dann, SE; Edgar, M,Blatchford CG SOLID STATE NUCLEAR MAGNETIC RESONANCE, Vol: 37Is: 3-4p75-812010

“The effect of particle size on the dehydration/rehydration behaviour of lactose"  Crisp, JL; Dann, SE; Edgar, M,Blatchford CG INTERNATIONAL JOURNAL OF PHARMACEUTICSVol: 391Is: 1-2p38-472010

"Enolate amination and derivatization of a pyrroloisoquinoline template towards novel peptidomimetics" Allin SM, Towler J, Gaskell SN, Saha B, Martin WP, Page PCB, Edgar M. TETRAHEDRON, Vol 66Is 49p: 9538-9544 2010

Teaching: CMB106; CMC001; CMP062

  • Plenary speaker, Leicester School of Pharmacy, DMU, 2017.
  • Guest speaker, JEOL NMR Users’ Meeting 2017
  • “Physical Methods and Techniques NMR Spectroscopy”, RSC Annual Reports, Progress in Chemistry, 2006 - 2012.

Papers

h-index = 14, first-name author most cited paper = 205 citations

1."Calculation of Proton Chemical-Shifts in Hydrocarbons"
    R.J. Abraham, M. Edgar, L. Griffiths, R.L. Powell.
    Journal of the Chemical Society-Chemical Communications, 1993, No.20, p.1544-1545.

2 "Mono-Fluoro and Di- Fluoro S.C.S. in Rigid Molecules"
    R.J. Abraham, M. Edgar, L. Griffiths, R.L. Powell.
    Journal of the Chemical Society-Perkin Transactions 2, 1995, No.3, p.561-567.

3. "Evaluation of Molecular Geometries by the Lanthanide-Induced Shift Technique"
    R.J. Abraham, S. Angiolini, M. Edgar, F. Sancassan.
    Journal of the Chemical Society-Perkin Transactions 2, 1995, No.11, p.1973-1979. 

4. "A Model for the Calculation of Proton Chemical-Shifts in Substituted Alkanes"
    R.J. Abraham, M Edgar, R.P. Glover, M.A. Warne, L. Griffiths.
    Journal of the Chemical Society-Perkin Transactions 2, 1996, No.3, p.333-341.

5. "The True Liquid Crystal Approach to Mesoporous Silica"
    G.S. Attard, M. Edgar, C.G. Göltner and J.W. Emsley
    Liquid Crystals for Advanced Technologies, MRS Proc., 425 1996.

6. "Deuterium NMR Spectroscopy of Solvents Adsorbed on the Surface of Mesoporous Silica"
     G.S. Attard, M. Edgar, C.G. Göltner and J.W. Emsley
     Liquid Crystals for Advanced Technologies, MRS Proc., 425 1996.

7. "The Conformational Analysis of 2-Substituted Fluoro-and Trifluoromethyl-benzaldehydes,
     Acetophenones and Methyl Benzoates by the Lanthanide Induced Shift (LIS) Technique"
     R.J. Abraham, S. Angiolini, M. Edgar, F. Sancassan.
     Journal of the Chemical Society-Perkin Transactions 2, 1997, No.1, p.41-48

8. "NMR investigations of Nanostructured Ceramics"
     M. Edgar, M. Schubert, H.H. Limbach and C.G. Göltner
     Berichte der Bunsen-Gesellschaft-Physical Chemistry Chemical Physics, 1997, 101, 1769 

9. "Analysis of the NMR Spectra of 2,2'-difluorobiphenyl in a Liquid Crystal Solvent"
     M. Edgar, J.W. Emsley and M.I.C. Furby
     J. Mag. Reson., 1997. 128, 105

10."The Structure of 2,2'-difluorobiphenyl in Solid and Liquid Crystalline Phases"
     B. Aldridge, G. De Luca, M. Edgar, S.J. Edgar, J.W. Emsley, M.I.C. Furby and M. Webster.
     Liquid Crystals, 1998 

11. "Symmetry and phase-selected NMR spectra of liquid crystalline sample"
      Carravetta M, Castiglione F, De Luca G, Edgar M, Emsley JW, Farrant RD, Foord EK,
      Lindon JC, Longeri M, Palke WE, Turner DL, J. Mag.
      Reson., 135 (2): 298-309, 1998

12. "The True Liquid Crystal Approach to Mesoporous Silica"
       G.S. Attard, M. Edgar, and C.G. Göltner
       Acta Materialia, 1998, 46, 751

13. Solid-State Transformations of Zinc Benzene-1, 4-Dicarboxylates Mediated
      by Hydrogen Bond-Forming Molecules
     M. Edgar, R. Mitchell, D.P. Tunstall, A.M.Z. Slawin, P. Lightfoot and P.A. Wrigh
     Chem. Eur. J., 2001, 7, No. 23, 5168-5175

14. The Structure Elucidation of a Novel Aluminium Methylphosphonate,
      Al3(CH3PO3)2·O·(OH)3 through a Combination of X-ray Powder Diffraction, Solid-State
      NMR Spectroscopy and Computational Energy Minimization
      Mark Edgar, Vinton J. Carter, Parmajit Grewal, Lesley-J. Sawers, David P. Tunstall,
      Paul A. Cox, Philip Lightfoot and Paul A. Wright.
      Chem Mater., 200214(8); 3432-3439.

15. "Preparation and Characterisation of a Novel Aluminium Methylphosphonate:
       Using a New Simulated Annealing Program and Powder X-ray Diffraction Data"
       Mark Edgar, Vinton Carter, David P Tunstall, Parmajit Grewal, Lesley-J. Sawers,
       Vincent Favre-Nicolin, Paul Cox, Philip Lightfoot and Paul A. Wright.
       Chem. Commun., 2002, 808-809

16. Structural Studies and Computer Simulation of the Inclusion of Aromatic Hydrocarbons
      in a Zinc 2,6-Naphthalene Dicarboxylate Framework Compound
      Devi, R. N.; Edgar, M.; Gonzalez, J.; Slawin, A. M. Z.; Tunstall, D. P.;
      Grewal, P.; Cox, P. A.;  Wright, P. A. J. Phys.
      Chem. B., 2004, 108(2); 535-543

17. “Stereoselective synthesis of the indolizinoindole ring system”
      Allin SM, Thomas CI, Allard JE, Duncton M, Elsegood MRJ, Edgar M
      Tet. Lett., 44 (11): 2335-2337, 2003

18.  “Applications of the amino-Cope rearrangement: synthesis of tetrahydropyran,
       delta-lactone and piperidine targets”
       Allin SM, Essat M, Pita CH, Baird RD, McKee V, Elsegood M, Edgar M, Andrews DM,
       Shah P, Aspinall I
       ORGANIC & BIOMOLECULAR CHEMISTRY 3 (5): 809-815 2005

19.  "The highly diastereoselective synthesis of oxazolidines derived from ketones
       and peudoephedrine or ephedrine”
       Buckley BR, Page PCB, Edgar M, Elsegood MRJ, Hayman CM, Heaney H, Rassias GA,
       Talib SA, Liddle J, Readshaw SA, Seaman CJ
       SYNLETT (6): 971-975 APR 6 2005

20. “A new paradigm in N-heterocyclic carbenoid ligands”
      Page PCB, Buckley BR, Christie SDR, Edgar M, Poulton AM, Elsegood MRJ, McKee V
      JOURNAL OF ORGANOMETALLIC CHEMISTRY 690 (24-25): 6210-6216 DEC 1 2005

21.  “Complementary stereoselective conjugate addition reactions on indolo[2,3-alpha]
       -quinolizine templates”
       Allin SM, Khera JS, Thomas CI, Witherington J, Doyle K, Elsegood MRJ, Edgar M
       TETRAHEDRON LETTERS 47 (12): 1961-1964, 2006

22. “Complementary routes for the stereoselective synthesis of functionalized benzoquinolizidine targets”
      Allin, Steven M., Duffy, Liam J., Bulman Page, Philip C., McKee, Vickie, Edgar, Mark, McKenzie, Michael J.,
      Amat, Mercedes, Bassas, Oriol, Santos, Maria M. M., Bosch, Joan
      TETRAHEDRON LETTERS 47 (32): 5713-5716, 2006

23. "A novel trisprotonated beta-dialdiminate cryptand
      Chin, A; Edgar, M; Harding, CJ,  McKee V,  Nelson J 
      DALTON TRANSACTIONS   Is: 32   p 6315-6326   2009

24. “The in-situ solid-state NMR spectroscopy investigation of alcoholic lactose suspensions "
      Crisp, JL; Dann, SE; Edgar, M,  Blatchford CG
      SOLID STATE NUCLEAR MAGNETIC RESONANCE, Vol: 37   Is: 3-4   p75-81  2010

25. “The effect of particle size on the dehydration/rehydration behaviour of lactose"
       Crisp, JL; Dann, SE; Edgar, M,  Blatchford CG
       INTERNATIONAL JOURNAL OF PHARMACEUTICS   Vol: 391   Is: 1-2   p38-47   2010

26.  "Enolate amination and derivatization of a pyrroloisoquinoline template towards
       novel peptidomimetics"
       Allin SM, Towler J, Gaskell SN, Saha B, Martin WP, Page PCB, Edgar M.
       TETRAHEDRON    Vol 66    Is 49    p: 9538-9544 2010   

27. "Synthesis of fluorinated fused benzofurans and benzothiophenes: Smiles-type rearrangement and
       cyclisation of perfluoro(het)aryl ethers and sulfides."
      Ponce Gonzalez, Julia; Edgar, Mark; Elsegood, Mark R J; et al.
      Organic & biomolecular chemistry  Volume: 9   Issue: 7   Pages: 2294-305   Published: 2011-Apr-7

28.  "A Novel Bifunctional Allyldisilane as a Triple Allylation Reagent in the Stereoselective
       Synthesis of Trisubstituted Tetrahydrofurans"
       Malkov, Andrei V.; Kysilka, Ondrej; Edgar, Mark; et al
       CHEMISTRY-A EUROPEAN JOURNAL  Volume: 17   Issue: 26   Pages: 7162-7166   Published: JUN 2011

29.  Intramolecular Carbonyl Nitroso Ene Reaction Catalyzed by Iron(III)
       Chloride/Hydrogen Peroxide as an Efficient Tool for Direct Allylic Amination
       Atkinson, Duncan; Kabeshov, Mikhail A.; Edgar, Mark; et al.
       ADVANCED SYNTHESIS & CATALYSIS  Volume: 353   Issue: 18   Pages: 3347-3351   Published: DEC 2011

30.  Studies on the double alkylation of 2,2-disubstituted-1,3-dithiacycloalkane-S-oxides:
       synthesis of tertiary thiol derivatives
       Fuchs, Christian; Edgar,  Mark ; Elsegood,  Mark R. J. ; Weaver, George W.
       RSC ADVANCES  Volume: 3   Issue: 44   Pages: 21911-21918   Published: 2013

31.  "Analysis of triacetone triperoxide complexes with alkali metal ions by electrospray
       and extractive electrospray ionisation combined with ion mobility spectrometry
       and mass spectrometry"
       A.R. Hill, Mark Edgar, Maria Chatzigeorgiou, James C. Reynolds, Paul F. Kelly and Colin S. Creaser,
       Eur. J. Mass Spectrom. 21, 265–274 (2015)

32."Effect of Anthropogenic Organic Complexants on the Solubility of Ni, Th, U(IV) AND U(VI)"
      Felipe-Sotelo, M , Edgar, M , Beattie, T , Warwick, P , Evans, NDM , Read, D ,
      JOURNAL OF HAZARDOUS MATERIALS, Volume: 300  Pages: 553-560 (2015).

33.  "Urinary Excretion and Metabolism of Miglustat and Valproate in Patients with
       Niemann-Pick Type C1 Disease:
       One- and Two- Dimensional Solution-State 1H NMR Studies"
       Journal of Pharmaceutical and Biomedical Analysis.
       Probert, F , Ruiz-Rodado, V , Zhang, XY , Vruchte, DT , Claridge, TDW , Edgar, M , Tocchio, AZ ,
       Lachmann, RH , Platt, FM , Grootveld, M ,
       JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Volume: 117  Pages: 276-288 (2015)

34.  "Design, Synthesis and Antitrypanosomal Activities of
       2, 6-Disubstituted-4,5,7-Trifluorobenzothiophenes."
       Bhambra, AS , Edgar, M , Elsegood, MRJ , Li, YQ , Weaver, GW, Arroo, RRJ, Yardley, V,
       Burrell-Saward, H , Krystof, V .
       EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, Volume: 108  Pages: 347-353 (2016)

35.  "Novel Fluorinated Benzimidazole Based Scaffolds and their Anticancer Activity in vitro"
       Avninder S. Bhambra, Mark Edgar, Mark R. J. Elsegood,
       Lynne Horsburgh, Vladimír Kryštof, Paul D. Lucas, Mariam Mojally, Simon J. Teat,
       Thomas G. Warwick, George W. Weaver, Fatemeh Zeinali.
       Journal of Fluorine Chemistry 188, p99-109 (2016)

 

 

 

 

                

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