Chemistry

Department staff

Location:

Centre for Analytical Science

Laboratories F2.07 and F2.08

Department of Chemistry

Loughborough University

Leicestershire

LE11 3TU

Tel: +44 (0) 1509 564100

 

Researchers:

Kayleigh Arthur 

Caitlyn Da Costa 

James Howard 

 

Associated researchers:

Dr Jim Reynolds

Dr Matthew Turner

 

Researchers:

Kayleigh Arthur, PhD student (K.Arthur@lboro.ac.uk)

In 2013 I graduated from Loughborough University with a First-class Hons MChem degree in Chemistry with Analytical Science. Later in 2013, I joined the Centre for Analytical Science at Loughborough University to start a PhD under the joint supervision of Professor Colin Creaser and Dr James Reynolds, with Owlstone Limited as an industrial collaborator.

Currently I am in the final year of PhD study at Loughborough University. The research focuses on the application of chip-based field asymmetric waveform ion mobility spectrometry (FAIMS) to enhance analysis via the development of the combination of FAIMS with liquid chromatography-mass spectrometry (LC-FAIMS-MS) for orthogonal separations. Applications under development include the targeted analysis of steroids and potential biomarkers of oxidative stress from biological matrices. Other research interests include an investigation into small molecule non-covalent complexes using FAIMS-MS and drift tube ion mobility-mass spectrometry.

 

Caitlyn Da Costa, PhD student (C.Da-Costa@lboro.ac.uk)

I obtained a BSc degree from Queen Mary University of London in Biochemistry with Forensic Science (2010) and an MSc with distinction from Loughborough University in Analytical Chemistry (2011). Currently I am in the final year of PhD study at Loughborough University in association with BP, with Tom Lynch and Sam Whitmarsh as my industrial supervisors. My research focuses on the application of desorption electrospray ionisation (DESI) and direct analysis in real time (DART) hyphenated with mass spectrometry, ion mobility-mass spectrometry (TWIMS) and high-field asymmetric waveform ion mobility spectrometry (FAIMS) for the targeted analysis of lubricants and oil additives (Da Costa et al., Rapid Commun. Mass Spectrom. 2013, 27, 2420-2424) directly from native surface materials and the characterisation of complex oil samples.

 

James Howard, PhD student, part time (James.Howard@lgcgroup.com)

I graduated from the University of Exeter in 2005 with a MChem in Chemistry.  As part of my degree I spent a year studying at Coastal Carolina University, USA, where I had the opportunity to undertake projects synthesising ionic liquids and evaluating the catalytic ability of picket fence porphyrins. These projects involved mass spectrometry and UV analysis, which sparked my interest in analytical science. Back at Exeter for my final year project, I continued my interest by using solid state multinuclear NMR for the structural determination of the molecular sieve AlPO-53. I then undertook a PGCE in Secondary Science at The University of Nottingham, and taught for a brief time, before joining LGC in 2007 as a Bioanalytical scientist. In 2010, with the support of LGC, I registered for a part time PhD at Loughborough University focusing on the development of mass spectrometry based methodologies for the high throughput quantitation of peptides in biological matrices. The peptide hormones glucagon and glucagon-like-peptide-1 (GLP-1) were selected as models for much of this research, as they are notoriously difficult to quantify. During our research we developed the first antibody-free LC-MS/MS based method capable of simultaneously determining endogenous glucagon and raised GLP-1 concentrations from human plasma, identified novel metabolites, and investigated novel strategies to reduce plasma protease degradation. I am currently writing up my thesis and preparing papers for publication.

 

Click here to go to Colin Creaser's personal web page