Chemistry

Research

Centre for Analytical Science

The Centre for Analytical Science (CAS), launched in March 2008, provides a focus for analytical research and educational activities in the Department of Chemistry.

Our research is focused on the development and application of new measurement systems and an important aspect of the work in CAS is the translation of advanced measurements into new research areas. Our objective is to understand and discern what fellow researchers would like to know and then to devise, develop or discover the appropriate measurement systems.

Our research is necessarily collaborative in nature and we work with biomedical, sport and materials scientists, clinicians, chemical engineers, physicists, pharmacists, psychologists and, of-course, fellow chemists. The Centre provides a point of contact for national and international collaborators from academia, industry and other research organisations.

In addition to research, the Centre is active in the training of analytical scientists through undergraduate (BSc and MChem) and postgraduate (MSc and PhD) programmes. These activities maintain Loughborough’s position as a major national centre for analytical science.

Academic staff, researchers and students associated with the Centre for Analytical Science are engaged in a range of research projects aimed at the development of novel methods and instrumentation for the structural and quantitative measurement of chemicals and biomolecules.

Current expertise and instrumentation includes atomic spectrometry, chromatography, ion mobility spectrometry, mass spectrometry, nanopores, aptamer technologies and chemometric/bioinformatics methods for processing data. The techniques and procedures developed are applied to solving problems in a variety of fields including biomedical, clinical, environmental, food, industrial process, forensic and pharmaceutical science.

  • Experimental design
  • Sampling of complex systems
  • Sample processing and preparation
  • Chromatography: GC, HPLC, UHPLC, nano-LC
  • Ion mobility spectrometry: aspirating ion mobility spectrometry, drift tube/TWIMS, differential mobility spectrometry/field asymmetric waveform ion mobility spectrometry
  • Mass spectrometry: quadrupole, ion trap, time of flight, Q-TOF, orbitrap
  • Hyphenated techniques: GC-MS, LC-MS, IM-MS, FAIMS-MS
  • ICP-MS: high resolution ICP-MS, laser ablation
  • X-ray diffraction: single crystal structure determination, powder diffraction (2 wavelengths)
  • Solid State NMR: multinuclear NMR, in situ suspension measurements
  • Data processing and data modelling